ID Number		982
Study Type		In Vitro
Model		900, 1800 MHz (GSM) exposure of human and rat cell cultures and analysis of heat shock protein expression, apoptosis, autophagy, etc.
Details		Human kerotinocytes and dermal fibroblasts were exposed to 900 MHz (GSM) at 2 W/kg for 48 hours using a wire patch antenna system. Cells were assessed following exposure for stress gene expression (HSP70), proliferation, morphology, and apoptosis. The authors report no effects due to RF exposure. In contrast, UVB and heat shock exposure did induce clear stress responses, but co-exposure with RF did not augment these responses. Ongoing studies involve astrocytic primary cultures and microglial cell lines exposed to 900 & 1800 MHz (GSM) and analysed for heat shock protein expression - addressing previous reports by Leszczynski et al (Differentiation (2002) 70:120-127). In other studies, rats are being exposed to 900 & 1800 MHz (GSM) and analysis of heat shock protein expression in brain and skin tissues by immunohistochemistry. AUTHORS' ABSTRACT: Aït-Aïssa et al. 2013 (IEEE #5296): The bioeffects of exposure to Wireless High-Fidelity (WiFi) signals on the developing nervous systems of young rodents was investigated by assessing the in vivo and in situ expression levels of three stress markers: 3-Nitrotyrosine (3-NT), an oxidative stress marker and two heat-shock proteins (Hsp25 and Hsp70). These biomarkers were measured in the brains of young rats exposed to a 2450 MHz WiFi signal by immunohistochemistry. Pregnant rats were first exposed or sham exposed to WiFi from day 6 to day 21 of gestation. In addition three newborns per litter were further exposed up to 5 weeks old. Daily 2-h exposures were performed blind in a reverberation chamber and whole-body specific absorption rate levels were 0, 0.08, 0.4 and 4 W/kg. 3-NT and stress protein expression was assayed in different areas of the hippocampus and cortex. No significant difference was observed among exposed and sham-exposed groups. These results suggest that repeated exposure to WiFi during gestation and early life has no deleterious effects on the brains of young rats.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		University of Bordeaux, France - fb.veyret@piom.u-bordeaux.fr
Funding Agency		France Telecom/CNET
Country		FRANCE
References		Sanchez, S et al. Radiation Research, (2007) 167:572-580 Sanchez, S et al. FEBS J., (2006) 273:5491-5507 Ait-Aissa , A et al. Radiat Res., (2013) 179:707-716
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