ID Number		959
Study Type		In Vivo
Model		2450 MHz (CW) exposure to rats and analysis of immune function
Details		Wistar rats were exposed to 2450 MHz (CW) RF at 1-2 W/kg for 2 hrs/day, 7 days/week, for up to 30 days and analyzed for immune and hematopoeitic endpoints. In initial studies, lung cells were collected by bronchoalveolar lavage after sacrifice. Exposure was reported to decrease the total cell number recovered by lavage and increase micronuclei in alveolar macrophages in a time and dose dependent manner. The authors state that multinucleated giant cells are common in some chronic inflammatory processes in the lung, and this may suggest an indication of pulmonary stress by MW exposure. No change in cell viability was reported. In a subsequent study, rats were exposed as above and peripheral blood lymphocytes analyzed for micronuclei. Exposure resulted in an increase in MN in bone marrow smears following some of the exposure treatments as well as an increase in immature erythrocytes in the peripheral circulation. The authors suggest a transient effect on proliferation and maturation or erythropoietic cells in rat bone marrow and sporadic appearance of MN immature red blood cells.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Inst Med Res Occup Health, Croatia
Funding Agency		Private/Instit.
Country		CROATIA (local name: Hrvatska)
References		Trosic, I et al. Exp Toxicol Pathol, (2006) 57:247-251 Busljeta, I et al. Int J Hyg Environ Health, (2004) 207:549-554 Trosic, I et al. Toxicol Lett, (2004) 154:125-132 Trosic, I et al. Mutagenesis, (2004) 19:361-364 Trosic, I et al. Mutat Res, (2002) 521:73-79 Trosic, I Int. J. Hyg. Environ. Health, (2001) 204:133-138
Comments		No SAR or adequate exposure assessment