ID Number		957
Study Type		In Vivo
Model		1.5 GHz (PDC) exposure to transgenic ("big Blue") mice and analysis of mutation frequency
Details		Big Blue mice were exposed to 1.5 GHz (PDC/TDMA) RF at 0, 0.67, and 2 W/kg (brain average SAR) for 90 min/day, 5 days/week, for 4 weeks. In this assay, the inserted B-gal gene is inactivated - mutations caused by the exposure agent to either the lac repressor (lac I gene) or the lac operator will cause the gene to no longer be repressed, thereby allowing a blue color staining of tissue. Histopathologically analysis of brain tissue revealed no gliosis or degenerative lesions and no apopticic cell death resulting from RF exposure. Further, no increase was found in mutation frequency of the lacI transgene in the brains of exposed mice. The authors conclude exposure to 1.5 GHz (PDC) RF is not mutagenic to mouse brain cells and does not create any increased hazard with regard to brain tumor development. Longer term assays in the lab are in progress.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Nagoya Institute of Technology, Japan
Funding Agency		ARIB, Japan, Ministry Ed, Sci, Japan
Country		JAPAN
References		Takahashi, S et al. Cancer Res., (2002) 62:1956-1960
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