ID Number		946
Study Type		In Vivo
Model		2.7 GHz (PW) exposure to rats and analysis of drug-induced seizures
Details		Sprague Dawley rats were exposed to 2.7 GHz (PW - 2 usec square wave pulses at 500 Hz) for 30 minutes at 0.75, 1.5, and 2.25 W/kg and then administered pentylenetetrazol (to induce seizures) and/or chlordiazepoxide (to protect against such seizures). Exposure in pentylenetetrazol-treated animals at the highest SAR resulted in shorter latency for seizure onset and an increase in seizure intensity. Exposure at the highest SAR in chlordiazepoxide-treated animals resulted in longer onset latencies for seizure. The authors, however, attributed these effects to core temperature elevations. More specifically, the hyperthermic effects of MW were attenuated by CDZ, and the hypothermic effects of CDZ were attenuated by MW. The dose-dependent seizure-inducing effects of drugs, however, was not directly affected by MW exposure.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Carleton Univ., Ottawa, Ontario, Canada
Funding Agency		DOD, Canada
Country		CANADA
References		Pappas, BA et al. Radiat. Res., (1983) 96:486-496
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