ID Number		868
Study Type		In Vivo
Model		2450 MHz (CW) exposure to rats, mice and rabbits and analysis of immune function
Details		CD-1 mice (pregnant dams) were exposed to 2450 MHz (CW) MW for 2x 4 hour periods during either day 1-6 (preimplantation) or day 6-15 (organogenesis) using a whole body SAR of 22 W/kg. Exposure resulted in a 2°C elevation of core temperature. Exposure did not affect leukocytes, lymphocytes, neutrophils or monocytes in the pregnant dams and further did not change the myeloid/erythroid ratio in bone marrow cells of the fetuses. In similar studies, Charles River rats were exposed as above for 8 hours at either 0.36-0.44 W/kg or 1.8-2.2 W/kg with no observed effects on, chromosome integrity, histamine content, size, function of peritoneal mast cells, hemoglobin, RBC and WBC count, hematocrit, or WBC subtype percentages. In earlier studies, New Zealand rabbits were exposed to 2450 MHz (CW) microwaves 23 hr/day for 180 days at an SAR of 1.5 W/kg (whole body average) and up to 17 W/kg peak at the head (4 exposed; 4 controls). In exposed animal blood samples there was a reduction in eosinophils (that normalized after 30 days), a decrease in albumin, calcium, albumin/total globulin (A/G) ratio, and an increase in myeloid/erythroid ratio. In addition, spleenic lymphocytes from exposed animals showed decrease stimulation by PHA, ConA, and pokeweed mitogen up to 30 days following exposure.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		NIEHS, RTP North Carolina, USA
Funding Agency		NIEHS, USA
Country		UNITED STATES
References		Galvin, MJ et al. Radiat. Res., (1984) 100:412-417 Galvin, MJ et al. Radiat. Res., (1982) 90:558-563 Ortner, MJ et al. Radiat. Res., (1981) 86:580-588 McRee, DI et al. J. Microwave Power, (1980) 15:45-52
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