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(Database last updated on Mar 27, 2024)
| ID Number | 827 | |
| Study Type | In Vivo | |
| Model | RF [900 MHz (GSM) and Wi-Fi] and low frequency EMF exposure of adult and prenatal mice and analysis of immune response and reproduction. | |
| Details | C57BL mice were exposed to 900 MHz (GSM) RF for 2hrs/day, 5 days/wk for 1, 2, or 4 weeks at SARs of 1 or 2 W/kg. Exposure did not affect spleen B cell lymphocyte or macrophage populations, T or B lymphocyte proliferation rate, IL2 / interferon / or other cytokine production, antibody response, or stimulated antigen response. The authors presented similar results at the 2007 EBEA meeting, reporting that RF exposure did not reduce the ability of normal B- and T- populations to recolonize immune compromised mice. In a subsequent study, C57BL/6 mice were exposed (or sham exposed) as above (900 MHz GSM at 2 W/kg for 4 wks) and bone marrow cells collected and used to repopulate lethal gamma irradiated mice of the same strain. The authors report all gamma irradiated mice survived, with no effect of prior RF exposure on immune cell type or proliferation and ability to colonize lymphoid organs and mature into functional immune cells. AUTHORS' ABSTRACT: Laudisi et al. 2012 (IEEE #5377): Wireless local area networks are an increasing alternative to wired data networks in workplaces, homes, and public areas. Concerns about possible health effects of this type of signal, especially when exposure occurs early in life, have been raised. We examined the effects of prenatal (in utero) exposure to wireless fidelity (WiFi) signal-associated electromagnetic fields (2450 MHz center-frequency band) on T cell development and function. Pregnant mice were exposed whole body to a specific absorption rate of 4 W/kg, 2 h per day, starting 5 days after mating and ending 1 day before the expected delivery. Sham-exposed and cage control groups were used as controls. No effects on cell count, phenotype, and proliferation of thymocytes were observed. Also, spleen cell count, CD4/CD8 cell frequencies, T cell proliferation, and cytokine production were not affected by the exposure. These findings were consistently observed in the male and female offspring at early (5 weeks of age) and late (26 weeks of age) time points. Nevertheless, the expected differences associated with aging and/or gender were confirmed. In conclusion, our results do not support the hypothesis that the exposure to WiFi signals during prenatal life results in detrimental effects on the immune T cell compartment. AUTHORS' ABSTRACT: Sambucci et al. 2011 (IEEE #5491): The development of the immune system begins during embryogenesis, continues throughout fetal life, and completes its maturation during infancy. Exposure to immune-toxic compounds at levels producing limited/transient effects in adults, results in long-lasting or permanent immune deficits when it occurs during perinatal life. Potentially harmful radiofrequency (RF) exposure has been investigated mainly in adult animals or with cells from adult subjects, with most of the studies showing no effects. Is the developing immune system more susceptible to the effects of RF exposure? To address this question, newborn mice were exposed to WiFi signals at constant specific absorption rates (SAR) of 0.08 or 4 W/kg, 2h/day, 5 days/week, for 5 consecutive weeks, starting the day after birth. The experiments were performed with a blind procedure using sham-exposed groups as controls. No differences in body weight and development among the groups were found in mice of both sexes. For the immunological analyses, results on female and male newborn mice exposed during early post-natal life did not show any effects on all the investigated parameters with one exception: a reduced IFN-³ production in spleen cells from microwaves (MW)-exposed (SAR 4 W/kg) male (not in female) mice compared with sham-exposed mice. Altogether our findings do not support the hypothesis that early post-natal life exposure to WiFi signals induces detrimental effects on the developing immune system. AUTHORS' ABSTRACT: Rosado et al. 2014 (IEEE #5792): Studies describing the influence of radiofrequency electromagnetic fields on bone marrow cells (BMC) often lack functional data. We examined the effects of in vivo exposure to a Global System for Mobile Communications (GSM) modulated 900 MHz RF fields on BMC using two transplantation models. X-irradiated syngeneic mice were injected with BMC from either RF-field-exposed, sham-exposed or cage control mice. Twelve weeks after transplantation, no differences in thymocyte number, frequency of subpopulations and cell proliferation were found in mice receiving BMC from either group. Also, in the spleen cell number, percentages of B/T cells, B/T-cell proliferation, and interferon ³ (IFN-³) production were similar in all groups. In parallel, a mixture of BMC from congenic sham- and RF-exposed mice were co-transplanted into lymphopenic Rag2 deficient mice. BMC from RF-exposed and sham-exposed mice displayed no advantage or disadvantage when competing for the replenishment of lymphatic organs with mature lymphocytes in Rag2 deficient mice. This model revealed that BMC from sham-exposed and RF-exposed mice were less efficient than BMC from cage control mice in repopulating the thymus, an effect likely due to restraint stress. In conclusion, our results showed no effects of in vivo exposure to GSM-modulated RF-fields on the ability of bone marrow (BM) precursors to long-term reconstitute peripheral T and B cell compartments. |
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| Findings | No Effects | |
| Status | Completed With Publication | |
| Principal Investigator | Dept of Environment / ENEA, Italy - marino@casaccia.enea.it | |
| Funding Agency | Agency Tech, Energy, Environ, Italy | |
| Country | ITALY | |
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