ID Number		798
Study Type		In Vivo
Model		2450 MHz (CW) exposure to mice and analysis of immune function
Details		CBA/J mice were exposed to 2450 MHz (CW) at 12-15 W/kg either 1x (on day 0) or 3x (on days 0, 3, and 6) for 30 minutes in a wave-guide. Exposure resulted in a slight increase in complement receptor-positive (CR+) B-cells in the spleen, but no concomitant increase in DNA, RNA, or protein synthesis in spleen, bone marrow, or peripheral blood lymphocytes. Other studies suggested that the increase in CR+ B-cells in the spleen was not due to alterations in lymphocyte recirculation pattern, but mediated by a soluble, humoral factor produced by cells within the spleen.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Georgetown University, Washington DC, USA
Funding Agency		Navy, USA
Country		UNITED STATES
References		Schlagel, CJ et al. J. Immunol., (1982) 129:1530-1533 Wiktor-Jedrzejczak, W et al. Bioelectromagnetics, (1980) 1:161-170 Sulek, K et al. Radiation Research, (1980) 83:127-137 Wiktor-Jedrzejczak, W et al. Radio Science, (1977) 12:209-219 Leach, WM Bull. N.Y. Acad. Med., (1980) 56:249-257 Schlagel, CJ et al. Bioelectromagnetics, (1980) 1:405-414 Wiktor-Jedrzejczak, W et al. Biomed., (1977) 27:250-252 Wiktor-Jedrzejczak, W et al. J. Immun., (1977) 118:1499-1502
Comments		There was a lack of appropriate positive and non-MW heat controls, as well as the lack of appropriate temperature monitoring in the exposed animals. However, with the relatively high SAR, it is likely that whatever is happening is due to heating effects.