ID Number		754
Study Type		In Vivo
Model		2450 MHz (CW) exposure to rabbits and analysis of eye pathology
Details		New Zealand white rabbits were exposed to 2450 MHz (PW-1000 Hz) at ~15.3 W/kg at the head for 30 minutes using a waveguide exposure system. Analysis of eye pathology by slit lamp was performed, and the threshold for cataract formation was determined as 285 mW/cm2 averaged over the central 2 cm of the waveguide, or a caloric load equivalent to 2.46 kcal. The authors further concluded that the rate of energy absorption, and not the peak electric field, is the significant parameter in the microwave induction of cataracts. In earlier studie, New Zealand white rabbits were exposed as above to 2450 MHz to determine thresholds for cataract induction. A single exposure at an incident power density of 250 mW/cm2 for 35-40 min of multiple exposures at 180 mW/cm2 for 1 hr/day for 20 consecutive days were required for cataract formation. Damaging MW exposure resulted in decreased ascorbic acid production, inhibition of DNA synthesis, and histopathological changes primarily in the lens epithelium.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		FDA, USA
Funding Agency		FDA, USA
Country		UNITED STATES
References		Foster, MR et al. Bioelectromagnetics, (1986) 7:129-140 Carpenter, RL Bull. N.Y. Acad. Med., (1979) 55:1048-1057 Carpenter, RL et al. Ann. N.Y. Acad. Sci., (1975) 247:142-154 Carpenter, RL Arch Ophthalmology., (1970) 84:1-1 Telles, NC et al. Arch Ophthalmology., (1970) 84:127-127 Carpenter, RL et al. J. Microwave Power, (1968) 3:3-19 Kinoshita, JH et al. Docum Ophthal, (1966) 20:91-103 Carpenter, RL et al. IRE Trans. Med. Electronics, (1960) 7:152-157 Carpenter, RL et al. Symposium on Biological Effects and Measurement of Radio Frequency/Microwaves. D.G. Hazzard, editor. Rockville, MD, February 16-18, 1977. HEW Publication (FDA) 77-8026., (1977) :352-379 Hagan, GL et al. BIOLOGICAL EFFECTS OF ELECTROMAGNETIC WAVES [BOOK], vol 1, C.C. Johnson and M.L. Shore (eds.), (1976) :143-155
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