ID Number		7
Study Type		In Vivo
Model		860 MHz (MiRS/TDMA) exposure to rats and analysis of brain tumors (ENU-initiated bioassay)
Details		Sprague Dawley (pregnant) rats were injected with 6.25 or 10 mg/kg ENU on gestation day 15 to produce brain tumors. Adult rats (60/group in sham, cage control, and multiple exposure groups) were exposed to an 850 MHz FM or MiRS/TDMA signal in a carrousel irradiator 6 hr/day, 5 days/wk for 2 years at ~1W/kg (brain average SAR). A record of body weight was taken, and examination of tumors of pituitary, thyroid, adrenal gland, mammary gland, and a detailed examination of CNS & PNS tumors, was performed. Results indicated no increase or change in incidence or mortality due to any neural or non-neural tumor type. In a follow-up study to examine whether pulsed 860 MHz exposure (6 h/d, 5 d/wk) affects tumor latency, serial sacrifice of animals was performed every 30 days between the ages of 171 and 325 days (for brain tumors initiated with 6.25 or 10 mg/kg ENU). There was no evidence that RF exposure affected the incidence, malignancy, volume, multiplicity, latency or fatality associated with any kind of neurogenic tumor.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		George Washington University, USA - resbcz@gwumc.edu
Funding Agency		Motorola
Country		UNITED STATES
References		Zook, BC et al. Radiation Research, (2006) 165:608-615 Zook, BC et al. Experimental and Toxicologic Pathology., (2005) 57:7-14
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