ID Number		671
Study Type		In Vivo
Model		2450 MHz (CW) exposure to mice and analysis of reproduction and survival of offspring
Details		C3H mice were exposed to 2450 MHz (CW or AM-100 Hz) MW 6 hr/day 8-wks at SARs of 4 W/kg (whole body average) in semi-restrictive cages (free to move only vertical to the E-field plane) in an anechoic chamber. Core temperatures were slightly but significantly increased by exposure (0.18 +/- 0.03 C). Exposure did not result in a reduction in pregnancy rate, preimplantation or postimplantation survival in pregnant dams or on the chromosomes of male spermatogonia (translocations, univalents, fragments & other exchanges. In an earlier study (Int J Radiat Biol (1986) 50:909-918, Mutation Research (1983) 122:155-161), mice exposed as above for 30 min/day 6 day/wk for 2 weeks showed marginal differences in sperm count, abnormal morphology, decreased pregnancy rate, and chromosome aberrations at high SAR levels, there was no decrease in embryo survival and the authors conclude their observations did not support the reports of germline effects by Manikowska-Czerska, et al. (J Hered (1985) 76:71-73). In another previous study, mice exposed as above for 30 minutes at SARs between 18 and 75 W/kg did show damage in the spermatogenic epithelial tissues with a threshold for spermatocyte reduction of 45 W/kg and an LD50 of 53 W/kg. A similar effect was also observed with non-MW heating in a water bath, however, indicating the results were thermal in nature.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		NRPB, UK - richard.saunders@nrpb.org.uk
Funding Agency		HPA (NRPB), UK
Country		UNITED KINGDOM
References		Saunders, RD et al. Int. J. Radiat. Biol., (1988) 53:983-992 Blackwell, RP et al. Int J Radiat Biol, (1986) 50:761-787 Saunders, RD et al. Mutation Res., (1983) 117:345-356 Kowalczuk, CI et al. Mutat. Res., (1983) 122:155-161 Saunders, RD et al. Int. J. Radiat. Biol., (1981) 40:623-632
Comments