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(Database last updated on Mar 27, 2024)
| ID Number | 652 | |
| Study Type | In Vivo | |
| Model | 2450 MHz (AM-120 Hz) exposure to rats and analysis of thermoregulatory behavior | |
| Details | Long-Evans, Wistar-Kyoto, and spontaneous hypertensive rats strains rats (male) were exposed to 2450 MHz (AM at 120 Hz) MW for 1-4 hours at SARs of up to ~13 W/kg. Exposures above ~2 W/kg increased colonic temperature and resulted in increased corticosterone levels and decreased T4, TSH and GH levels. In contrast, exposure first to lower levels of MW followed by higher MW exposures resulted in less colonic temperature increase and lowered corticosterone levels. Acclimation was evident after repeated exposures. Thermal exposures also affected PRL, corticosterone, TSH levels, stress, and behavioral responses, as well as serum alkaline phosphatase (AP), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and lactic dehydrogenase (LDH) activity. Measurements made 24 hours after exposure showed an increase in GPT and GOT. The authors suggest a threshold body temperature for the rat of between 40.8 and 41.5 C for MW-induced effects. By extrapolation, it was estimated that in humans, whole body averaged SARs of above 0.4 W/kg would be required to see disturbances in thyroid function. The authors conclude that increased adrenocortical secretion occurs as a result of increased colonic temperature, and therefore changes in thermoregulatory function are critical determining factors in adrenal response to MW. |
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| Findings | Effects (only at thermal levels) | |
| Status | Completed With Publication | |
| Principal Investigator | Univ. of Rochester, NY, USA | |
| Funding Agency | NIEHS, USA | |
| Country | UNITED STATES | |
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