ID Number		649
Study Type		In Vitro
Model		2450 MHz (PW - 16, 60 Hz) exposure to human mononuclear leukocytes and analysis of growth and activation
Details		Human mononuclear leukocytes were infected with influenza virus and exposed to 2450 MHz (CW & PW at 16 or 60 Hz) microwaves for a total of 2 hr (starting at 4 hrs, 1 day, or 2 days following infection) at SARs of up to 4 W/kg in a waveguide system (described by Lu et al. J Microwave Power, 1983, 18:121). DNA synthesis was measured following stimulation with phytohemagglutinin. Exposure with either CW or PW microwaves had no effect on leukocyte viability or mitogen stimulated DNA synthesis in either uninfected (control) or influenza virus-infected leukocytes for up to 1 week after exposure. In earlier studies, human mononuclear leukocytes were exposed as above (2450 MHz PW- at 16 or 60 Hz, 2 hr in a waveguide, SARs between 0.29 - 4 W/kg). MW exposure had no effect on cell viability, DNA, and total protein synthesis. In prior studies (Science 220(1983):318-320; Cancer Res (1985) 45:3076-3082), exposures to peripheral human leukocytes resulted in no detectable effects on cell viability, or unstimulated or stimulated DNA, RNA, total protein, or interferon synthesis for up to 1 wk after exposure unless exposures were heat generating. The authors interpreted the results as highly reproducible and providing no evidence that current safety standard recommendations are inappropriate.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Univ. of Rochester School of Medicine, USA
Funding Agency		Private/Instit.
Country		UNITED STATES
References		Roberts Jr., NJ et al. Radiation Research, (1987) 110:353-361 Roberts, NJ et al. IEEE Trans Microwave Theory Tech, (1984) 32:803-807
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