ID Number		648
Study Type		In Vivo
Model		2450 MHz (CW) exposure to rats and analysis of blood brain barrier permeability
Details		Sprague Dawley rats were exposed to 2450 MHz (CW) MW for 30, 90 or 180 minutes at SARs of 4 to 13 W/kg (brain average). During exposure, temperature was monitored within the cerebral cortex, hypothalamus, cerebellum and medulla. At 4 W/kg, slight elevations in brain and colon temperature were observed. Permeability of Na-fluorescein, HRP, and 14-C sucrose indicated a correlation between BBB permeability and brain temperature. The authors conclude that MW effects on the blood brain barrier are mediated by temperature dependent changes in endothelial cell function, and not as a direct non-thermal effect of the MW themselves
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Univ. of Rochester Med Center, USA
Funding Agency		NIH, USA
Country		UNITED STATES
References		Williams, WM et al. Brain Res. Rev., (1984) 7:165-170 Williams, WM et al. Brain Res. Rev., (1984) 7:171-181 Williams, WM et al. Brain Res. Rev., (1984) 7:183-190 Williams, WM et al. Brain Res. Rev., (1984) 7:191-212 Williams, WM et al. Brain Res. Rev., (1984) 7:165-170 Williams, WM et al. Brain Res. Rev., (1984) 7:171-181 Williams, WM et al. Brain Res. Rev., (1984) 7:183-190 Williams, WM et al. Brain Res. Rev., (1984) 7:191-212
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