ID Number		637
Study Type		In Vivo
Model		2450 MHz (CW) exposure to mice and analysis of BBB permeability of drugs
Details		Swiss Webster and IRC mice were exposed to 2450 MHz (CW) RF for 10 minutes at an SAR of up to 53 W/kg and treated with both apomorphine (a dopaminergic agonist to induce climbing behavior) plus domperidon (a dopaminergic antagonist that poorly penetrates the BBB to block the effects). MW exposure assisted in allowing domperidon across the BBB to block the apomorphine effects. In similar studies looking at the effects of methylatropine to antagonize central cholinomimetic drug effects (Fed Proc, 1982, 41:1576), carbidopa (CD) or 6-hydroxoydopamine (6-HD) to decrease brain norepinephrine and dopamine levels (Fed Proc (1983) 42(4):1122), morphine (to induce a tail-flick response) and its antagonists (J Bioelectr (1986) 5:35-46) and of pilocarpine (to induce hypothermia) and oxotremorine (to induced ataxia) and their antagonists (Radiat Res (1986) 105:328-340), the effects of drugs were enhanced by MW exposure. The authors suggest MWs facilitate drug action by increasing permeability across the blood brain barrier.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Univ henri Poincare, Nancy France
Funding Agency		AF, USA
Country		UNITED STATES
References		Quock, RM et al. Bioelectromagnetics, (1987) 8:45-55
Comments