ID Number		636
Study Type		In Vivo
Model		2450 MHz (CW) exposure to mice and analysis of BBB permeability by peripherally injected virus passage to the brain
Details		Swiss-Cox mice were exposed to 2.45-GHz (CW) MW for 10-minutes in a waveguide (TE10 mode) at SARs of 23.7, 45.5, 54.2, or 97.7 W/kg. Exposures increased rectal temperature by 1.5, 2.0, 3.8, and 7.2 C, respectively. Microwave exposure was repeated at 1, 2, 4, and 8 days after peripheral JEV virus inoculation. Lethality (indicating virus permeability through the BBB) was increased in a dose-dependent fashion, and at the highest exposure level was 4 fold that of control animals. Mice did not become tolerant or sensitized by pre-microwave exposure. Although no hypothesis for a mechanism was offered, thermal effects at these high exposure levels are likely.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Johns Hopkins Medical Inst, USA
Funding Agency		NIH, USA
Country		UNITED STATES
References		Lange, DG et al. Bioelectromagnetics, (1991) 12:335-348
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