ID Number		616
Study Type		In Vivo
Model		1300, 2450 MHz (CW) exposure to rats and analysis of behavior and attenuation of drug-induced hypothermia
Details		Long Evans rats were exposed to 2450 MHz (CW) RF at an average SAR of 0.3 W/kg for 45 minutes and then treated with ethanol to induce hypothermia. In addition, some rats were previously injected with the neurotoxin 6-OHDA (to lesion central noradrenergic neurons) or the beta-adrenergic antagonists propranolol or CGP-12177 (to antagonize EtOH-induced hypothermia). Microwave exposure attenuated EtOH hypothermia (especially at lower doses of EtOH), but did not effect the development of tolerance to EtOH hypothermia. In rats given 6-OHDA + EtOH, microwave exposure also attenuated EtOH hypothermia. Propanolol antagonized EtOH hypothermia in a dose dependent manner, and microwave exposure eliminated the propanolol effect. CGP-12177 antagonized EtOH induced hypothermia, but microwave exposure had an additive effect with CGP-12177. The authors interpret these results as indicating a NE mediation of EtOH-induced hypothermia, and suggest that microwave exposure in some way mimics the role of beta-adrenergic antagonists. In a previous study it was found that the thermal threshold to induce convulsions in rat pups using 918 MHz (CW) exposure for 10 minutes was either 9.4 W/kg for 13 day old rats or 18.0 W/kg for 17 day old rats, suggesting an age dependent threshold. The authors also showed that brain tissue had a faster equilibration rate than colonic temperature.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Los Alamos Natl. Lab, USA
Funding Agency		AF, USA
Country		UNITED STATES
References		Hjeresen, DL et al. Health Phys., (1989) 56:767-776 Klauenberg, BJ et al. Health Physics, (1991) 60:282-284 Hjeresen, DL Health Physics, (1991) 61:576- Hjeresen, DL et al. Bioelectromagnetics, (1988) 9:63-78 Hjeresen, DL et al. Bioelectromagnetics, (1983) 4:341-355 Hjeresen, DL et al. LACK OF BEHAVIORAL EFFECTS OF HIGH-PEAK-POWER MICROWAVE PULSES FROM AN AXIALLY EXTRACTED VIRTUAL CATHODE OSCILLATOR, (1989) :- Hjeresen, DL et al. BEHAVIORAL EFFECTS OF 1300 MHz HIGH-PEAK-POWER-MICROWAVE PULSED IRRADIATION, (1990) :-
Comments