ID Number		598
Study Type		In Vivo
Model		460 MHz (CW) exposure to rabbits and analysis of thyroid and adrenal gland function
Details		Chinchilla rabbits (males 2-2.5 kg) were exposed to 460 MHz RF (CW) for 6 minutes/day for 10 days. Exposure was given to a region proximal to the hypothalamus (19.5 W/kg), adrenal glands (6.2 W/kg), thyroid gland (20.8 W/kg), or the thymus (9.3 W/kg) using a 40 mm diameter contact applicator. The authors concluded from an analysis of membrane changes and chromatin that exposure of the hypothalamus and adrenal glands resulted in a decreased activity of thymocytes while exposure to the thymus itself resulted in a stimulation of thymocytes. In a similar study, rabbits were exposed at the level of the temporo- parietal region of the brain as above. Exposure resulted in a decrease in T-lymphocyte activity, short term serum Ig level changes, decreased thyroid function, increased T4 and TSH levels, and an increase in testosterone and 11-hydroxycorticosteroid levels. The authors suggest that exposure activated the hypothalamo-hypophyseo-adrenal system resulting in increased adrenal cortex and decreased thyroid function.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Ministry of Health of the USSR, Russia
Funding Agency		Nat'l Res Prog, Russia
Country		RUSSIAN FEDERATION
References		Bogolyubov, VM et al. Radiat. Res., (1988) 115:44-53 Bogolyubov, VM et al. Bull. Exp. Biol. Med., (1987) 102:1118-1120
Comments