ID Number		577
Study Type		In Vivo
Model		10 MHz (CW) exposure to mice and rats and analysis of teratogenic and developmental effects
Details		Sprague Dawley rats were exposed to 10 MHz (CW) RF on gestation day 9 or 13 for 0, 40, 50, or 60 minutes at an SAR of 6.6 W/kg. Exposures increased rectal temperature from 38 to 42 degrees. Rats were then treated with 2-methoxyethanol and rat pups were studied for external, skeletal, and visceral developmental effects after birth. While hyperthermic exposure early in development (day 9 of gestation) had little effect, hyperthermic exposures later in development (day 13 of gestation) did produce significant effects, mainly in the forepaw digits. Additional studies by the same group demonstrated that significant hyperthermia had to take place before developmental abnormalities occured. The authors further showed that under similar conditions of exposure, simultaneous exposure with 2-methoxyethanol (2ME) that alone would have produced a 10-20% incidence of external malformations now produced a 76% malformation rate with more severe malformations. The threshold for a synergistic effect between 2ME and RF was found to occur at intermediate levels of the dose ranges (75, 100, 125 mg/kg 2ME and 30 minutes of RF exposure. The authors concluded that hyperthermic MW exposure synergized with 2ME to produce teratogenic effects.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		NIOSH, USA
Funding Agency		AF, USA
Country		UNITED STATES
References		Nelson, BK et al. Reprod. Toxicol., (1999) 13:137-145 Nelson, BK et al. Occup. Hyg., (1996) 2:303-310 Nelson, BK et al. Bioelectromagnetics., (1997) 18:349-359 Nelson, BK et al. Teratology, (1994) 50:275-293 Nelson, BK et al. Teratology, (1991) 43:621-634
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