ID Number		54
Study Type		In Vitro
Model		900 MHz (GSM) exposure to yeast and analysis of recombination rate, mutation (reverse and forward), and sister chromatid exchange (SCE)
Details		Sacharomyces cerevisiae containing plasmid DNA constructs were exposed to 900 MHz (GSM) RF at 0.13 and 1.3 W/kg either with or without the alkylating agent methyl methansulfonate. Exposure was from a directional antenna (900 MHz, 10 W max, GSM modulation) and was performed in two Faraday cages (exposed and sham parallel treatments). Mutation rate was measured by forward mutation assay (CAN1 locus) and a wide-range assay measuring the induction of respiration-deficient (petite) clones that have lost mitochondrial function. Two additional assays measured recombinogenic effects of RF exposure to detect possible effects on genomic stability (intrachromosomal, deletion-formation assay and an intragenic recombination assay in the ADE2 gene). No effects of RF exposure were observed, either with or without methyl methansulfonate. In a related study presented at the BEMS 2nd World Congress, E.coli was also analyzed for reverse mutation at his-3 and ade-2 loci and forward mutation to canavanin resistance. Exposure resulted in no effect.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		University of Bern, Switzerland
Funding Agency		Swiss Telecom
Country		SWITZERLAND
References		Gos, P et al. Bioelectromagnetics, (2000) 21:515-525 Gos, P et al. Bioelectromagnetics, (1997) 18:142-155
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