ID Number		500
Study Type		In Vivo
Model		2450 MHz (CW) exposure to rats and analysis of blood brain barrier permeability
Details		Wistar rats were perfused with Evans blue dye or 86Rb and exposed to 2450 MHz (PW- 10 usec pulse width, 500 pulses/sec) for up to 20 minutes at SARs of up to 240 W/kg in the brain. While exposures of 200 W/kg and below did not affect blood brain barrier permeability, exposure at 240 W/kg increased Evans blue dye and 86 Rb transfer across the blood brain barrier and into the cortex, hippocampus, and midbrain. In addition, after 10 minutes at this exposure level cardiac output and blood PaCO2, PaO2, and pH increased evidence of hyperventilation was detectable as elevated pH and decreased PaCO2. At this exposure level, core body temperature was increased more than 1 degree C and brain temperature was increased to ~ 43 degrees C. The degree of staining, however, was diminished with recovery time after exposure indicating reversibility of microwave hyperthermia-induced blood-brain barrier alterations. In other studies (Bioelectromagnetics (1986) 7:405-414), ethanol administration was shown to reduce local hyperthermia and Evans blue dye transport across the blood brain barrier due to microwave exposure.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		University of Illinois, USA - james.c.lin@uic.edu
Funding Agency		NIH, USA
Country		UNITED STATES
References		Neilly, JP et al. Bioelectromagnetics, (1986) 7:405-414 Goldman, H et al. Bioelectromagnetics, (1984) 5:323-330 Lin, JC et al. Radiat. Res., (1982) 89:77-87 Lin, JC et al. Bioelectromagnetics, (1980) 1:313-323 Lin, JC Radio Sci. Bull., (2005) 315:33-38
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