ID Number		497
Study Type		In Vivo
Model		2450 MHz (PW) exposure to rats and analysis of blood brain barrier permeability
Details		Sprague Dawley rats were injected with a fluorescent dye and exposed to 2450 MHz (PW-10 usec pulses, 100 pulses per second) microwaves for 5 – 120 minutes at an SAR of ~2 W/kg in the far field in an anechoic chamber. Exposure for 30 minutes or more resulted in an increase of the fluorescent tracer molecule across the blood brain barrier indicating pinocytotic uptake by brain capillary endothelial cells. This effect was significantly reduced by pretreatment with colchicine to block microtubular mediated pinocytosis, suggesting microwave exposure may alter the pinocytotic activity of capillary endothelial cells. In a subsequent study, rats were exposed to thermal levels of MW (SAR of 72.4 W/kg) for 30 minutes/day for 4 days. Exposure resulted in increased fluidity and a decrease in the saturated/unsaturated fatty acid ratio of liver membrane preparations. MW exposure also decreased Mg-ATPase activity and increased Na/K-ATPase activity. These effects were somewhat different than the effect of non-RF heat controls, and the authors conclude that cell membranes respond differently to MW vs radiant heat sources
Findings		Effects
Status		Completed With Publication
Principal Investigator		Johns Hopkins Medical Institute, USA
Funding Agency		Private/Instit.
Country		UNITED STATES
References		Phelan, AM et al. Bioelectromagnetics, (1992) 13:131-146 Neubauer, C et al. Bioelectromagnetics, (1990) 11:261-368
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