ID Number		474
Study Type		In Vivo
Model		50, 147, 200, 450, 591, 2450 MHz (CW, AM 4-32Hz, PW) exposure to rats and chicks and analysis of brain biochemistry
Details		Sprague-Dawley rats (with a fluorometer positioned directly above a surgical opening through the skull to visualize fluorescence in the cerebral cortex) were exposed to 200 MHz (CW), 591 MHz (CW, AM between 4 and 32 Hz, or PW-250 or 500 pulses per second, 5 usec/pulse) at SARs of 0.02-1.84 W/kg, or 2450 MHz (CW) RF for between 0.5 and 5 minutes at up to 5.8 W/kg. Brain temperature was monitored with a vitek probe in animals exposed under identical conditions. Brain metabolites were measured in live animals during exposure through the opening in the skull. Exposure using 591 MHz CW, AM, or PW decreased creatine phosphate, and exposure at 200 and 591 MHz decreased ATP levels. Non-RF hyperthermia had the same effect on CP and ATP. In some studies, 591 MHz CW increased NADH levels brain, and in other studies 200 and 591 MHz CW exposure decreased NADH levels. There were no apparent effects using 2450 MHz CW exposure. The authors suggest these results reflect a change in brain energy metabolism and a microwave effect on mitochondrial electron transport chain, ATP production, and the CP-kinase reaction pathway.
Findings		Effects
Status		Completed With Publication
Principal Investigator		EPA, RTP North Carolina, USA
Funding Agency		EPA, USA
Country		UNITED STATES
References		Sanders, AP et al. Bioelectromagnetics, (1985) 6:89-97 Weil, CM et al. Bioelectromagnetics, (1984) 5:293-304 Sanders, AP et al. Bioelectromagnetics, (1984) 5:419-433 Sanders, AP et al. Bioelectromagnetics, (1984) 5:63-70 Sanders, AP et al. Bioelectromagnetics, (1980) 1:171-181
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