ID Number		454
Study Type		In Vivo
Model		9 GHz (PW) exposure to CD-1 mice and analysis of immune response
Details		CD-1 female mice infected with an LD50 dose of Streptococcus pneumoniae Type III were exposed to 2450 MHz (CW) microwaves at an SAR of ~ 6.8 W/kg for 4 hr/day for 5 days starting on the day of infection at ambient temperatures of 19, 22, 25, 28, 31, 34, 37, and 40 C. Microwave exposure increased survival at ambient temperatures of 19-31 C but had no effect above 31 C. In a similar study, CD-1 mice were immunized as above and exposed (beginning on the first day of immunization) to 9 GHz (PW - 1.0 usec pulses, 1 W/cm2 peak power, at a repetition rate of 970-1000/sec) microwaves 2 hr/day for 5 days at SARs of ~4.7 or 0.47 W/kg. Mice were then challenged with an LD 50 dose of virulent S pneumoniae. No differences in total mortality was observed in the exposure groups as compared to control. In the highest exposure group, however, hemagglutination titers were increased, and time to mortality appeared delayed, although after 10 days mortality was the same as controls. No changes in RBC counts, WBC counts, differential counts, hemoglobin values, or hematocrits was observed due to exposure. The authors attribute any increase in survival in MW exposed animals to stimulation of the immune system and not to abdominal temperatures capable of attenuating the virulence of S. pneumoniae (41 C).
Findings		No Effects
Status		Completed With Publication
Principal Investigator		EPA, RTP North Carolina, USA
Funding Agency		EPA, USA
Country		UNITED STATES
References		Liddle, CG et al. Bioelectromagnetics, (1986) 7:91-94 Liddle, CG et al. Bioelectromagnetics, (1987) 8:295-302 Liddle, CG et al. Bioelectromagnetics, (1980) 1:397-404
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