ID Number		435
Study Type		In Vivo
Model		100, 1700, 2450 MHz (CW, PW) exposure to rabbits and analysis of hematologic and immune parameters
Details		New Zealand and Dutch rabbits were exposed to various RF signals and studied for immune parameters. In a study in rabbit neutrophils, exposure was at 100 MHz (CW, AM at 20 Hz) for 30-60 minutes at SARs of 120 to 340 W/kg. Viability and phagocytotic activity were not affected by exposure if temperature was held constant at 37 degrees. The authors conclude that previously reported microwave effects in vivo are either indirect (i.e.; mediated by the neuroendocrine system) or involve radiation-induced tissue heating. When rabbits were exposed to either 1700 or 2450 MHz (CW, PW) at power densities of between 5 - 55 mW/cm2 for 2 hours and blood samples taken immediately after exposure and at 1, 2, and 7 days following, the authors reported statistically significant changes in glucose, blood urea nitrogen, uric acid, serum triglycerides, and creatine phosphokinase (CPK) that were dose dependent. One study reported 18% change at 5 mW/cm2 [CW], 29% change at 10 mW/cm2 [CW], 44% change at 25 mW/cm2 [CW]). No effects on other serum components were observed (calcium, inorganic phosphate, cholesterol, total protein, alkaline phosphatase, lactic acid, dehydrogenase, and serum glutamic oxalic transaminase). The authors suggest from behavioral observations and temperature measurements that the rabbits were able to compensate for the thermal burden at 5 and 10 mW/cm2 and maintain temperature, but not at 25 mW/cm2 for 2 hours. The authors also reported mild repairable nephrosis and effects on sleeping time in phenobarbital sedated rabbits. The authors also report that an ambient temperature of 40 degrees for 2 hours also elevated some of these parameters, and conclude that there dose dependent effects are due to a nonspecific thermal stress with RF exposure.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Medical College of Virginia, USA
Funding Agency		AF, USA
Country		UNITED STATES
References		Cleary, SF et al. Bioelectromagnetics, (1985) 6:53-60 Cleary, SF et al. Bioelectromagnetics, (1980) 1:345-352 Wangemann, RT et al. Radiat. Environ. Biophys., (1976) 13:89-103 Cleary, SF et al. NTIS Document No. AD-A091 813/6, (1977) :1-74 Cleary, SF NTIS Document No. AD-A096 166/4, (1977) :1-62 Cleary, SF et al. BIOLOGICAL EFFECTS OF ELECTROMAGNETIC WAVES. U.S. Department of Health, Education and Welfare. , (1976) 1:311-322
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