ID Number		334
Study Type		In Vivo
Model		915, 2450 MHz, 6 GHz (CW) exposure to rats and analysis of morphological and behavioral endpoints.
Details		Wistar rats exposed to 915 & 2450 MHz and 6 GHz (CW) RF in an anechoic chamber and analyzed various physiologic, behavioral and teratogenic effects and morphological changes. to 915 MHz for 6 hr/day throughout pregnancy at an SAR of ~3.57 W/kg (whole body average to the dam) did not result in any consistent temperature increase and did not affect many parameters including surface righting, air righting, auditory startle, visual placing, eye opening, T-maze, conditioned avoidance response, open field, activity wheel, forelimb hanging, swimming. Tissue samples and organ weights for the brain, liver, kidneys, and gonads were collected, and no effects of exposure were observed on malformations, physiology, or reflex test results, body/organ weight ratios, or subsequent breeding ability. Exposure did, however, increase activity in offspring. Exposure to 2450 MHz for 6 hr/day at 7.28 W/kg throughout pregnancy resulted in a significant decrease in activity once the pups reached adult age. Exposure to 6 GHz for 6 hr/day throughout pregnancy (at 7.28 W/kg whole body average) resulted in a slight but statistically significant retardation in term weight and lowered monocyte count in the dams. Exposed offspring were generally more active in open field testing and exposed female offspring showed decreased performance in the water T-maze (swimming) test. In the 6 GHz study, kidney weights were higher in exposed male and female offspring than in controls, and liver weights were higher in exposed female offspring than in controls. RF exposure did not cause significant reproductive effects in any of the experiments in the absence of hyperthermia.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Jefferson Medical College, Philadelphia, USA
Funding Agency		Private/Instit.
Country		UNITED STATES
References		Graham , JM et al. Teratology, (1999) 59:307-313 Brent , RL Teratology, (1999) 59:182-204 Jensh, RP Reprod. Toxicol., (1997) 11:601-611 Brent, RL Seminars in Oncology, (1989) 16:347-368 Brent , RL Clin Perinatol., (1986) 13:615-648 Jensh, RP Radiat. Res., (1984) 97:272-281 Jensh, RP Radiat. Res., (1984) 97:282-301 Brent , RL Curr Probl Pediatr., (1984) 14:1-87 Brent , RL Clin Obstet Gynecol, (1983) 26:484-510 Jensh, RP et al. J. Toxicol. Environ. Health, (1983) 11:23-35 Jensh, RP et al. J. Toxicol. Environ. Health, (1983) 11:37-59 Jensh, RP et al. J. Am. Coll. Toxicol., (1982) 1:73-90 Jensh, RP et al. Radiat. Res., (1982) 92:160-171 Brent, RL et al. Reproductive toxicology., (1993) 7:535-580
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