ID Number		323
Study Type		In Vivo
Model		900 MHz (GSM) exposure to mice and analysis of cancer (MX-initiated bioassay)
Details		Wistar rats (n = 4 groups of 72 each, female) were exposed to 900 MHz (GSM) at 0.3 W/kg and 0.9 W/kg, 2 h/d, 5 d/w for 104 weeks, and to 3- chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (also called MX) continuously in drinking water. Tumor induction by MX described previously by Komulainen et al., 1997, J. Natl. Cancer Inst. 89:848- 856. Periodic blood samples over the course of the study, as well as brain and liver samples at the end of the study were analyzed for DNA damage and cytogenic abnormalities. Total tissue pathology was also performed. The authors initially reported a statistically significant increases in vascular tumors of the mesenteric lymph nodes in the highest exposure group, although additional histopathology suggested the difference was due to an unusually low frequency in the sham animals and not an unusually high number in the RF exposed group. With the large number of endpoints examined, a few additional isolated endpoints were also reached statistical significance, but the small number of tumors for each and the lack of consistency with related endpoints lead the authors to conclude these were also the result of expected variability as is common in aged rats.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		University of Kuopio, Finland - juutilainen@uku.fi
Funding Agency		EU, CEMFEC, EU 5th Framework, Europe
Country		FINLAND
References		Heikkinen, P et al. Radiation Research., (2006) 166:397-408
Comments		The study belongs to the consortium CEMFEC funded by EU Fifth Framework programme "Quality of Life and Management of Living Resources"