ID Number		3100
Study Type		In Vivo
Model		Results with primary cerebral cortex neurons of rats radiated 3 days (0.3-3 THz, 100 ¼W) suggest specific frequencies and energies of terahertz radiation as a novel neuromodulation technology for the treatment or intervention of diseases such as neurodevelopmental disorders.
Details		Authors' abstract for IEEE #8931: Terahertz waves are located in the energy level range of hydrogen bonding and van der Waals forces, and can directly couple with proteins to excite the nonlinear resonance effect of proteins. Therefore, terahertz can affect the conformation of proteins, the structure and function of neurons. Primary cerebral cortex neurons of SD rats were cultured in vitro. Neurons were radiated 3 days by THz with frequency of 0.3-3THz and a power of 100¼W; record the growth and development indicators of neurons (Cell body area, total length of process). At the end of a radiation programme, Western blotting was used to detect the protein expressions of GluA1, GluN1, postsynaptic density protein-95(PSD-95) and synaptophysin 38(SYP-38). After the first day of terahertz radiation, the increase in cell area increased by 144.9% (P<0.05); On the second and third days of terahertz radiation, the growth value of the total length of neuronal neurites increased by 65.1% (P<0.05) and 109.4% (P<0.05), respectively; Three days after terahertz irradiation, the protein expressions of GluA1 and SY-38 were increased by 38.1% (P<0.05) and 19.2% (P<0.05), respectively. The results show that (1)The use of Low intensity of broadband terahertz in this study will not cause the death of cortical neurons, and will not affect their growth regularity;(2)Low intensity of broadband terahertz radiation. can promote the growth of cortical neuron cell bodies and processes, but the effects on cortical neuron cell bodies and processes are different. This may be related to the developmental cycle of cultured cortical neurons in vitro, and there is a cumulative effect on the promotion of neuronal processes by low intensity of broadband terahertz;(3) The promotion of neuronal growth and development by low intensity of broadband terahertz radiation may be related to the proportion of AMPA receptor subtypes and the expression of presynaptic specific protein SY-38. These results herald specific frequencies and energies of terahertz radiation as a novel neuromodulation technology for the treatment or intervention of diseases such as neurodevelopmental disorders.
Findings		Effects
Status		Completed With Publication
Principal Investigator
Funding Agency		?????
Country		CHINA
References		Ma, S et al. Acta Physica Sinica. , (2022) :-
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