ID Number		3044
Study Type		In Vitro
Model		Human skin fibroblasts were exposed in vitro to high intensity terahertz energy (intensity of 30 GW/cm2 and electric field strength of 3.5 MV/cm).
Details		AUTHORS' ABSTRACT: Sitnikov et al. 2022 (#9090) The data is obtained on the effect of high-intensity pulses of terahertz (THz) radiation with a broad spectrum (0.2–3 THz) on cell cultures. We have evaluated the threshold exposure parameters of THz radiation causing genotoxic effects in fibroblasts. Phosphorylation of histone H2AX at Ser 139 (γH2AX) was chosen as a marker for genotoxicity and a quantitative estimation of γH2AX foci number in fibroblasts was performed after cell irradiation with THz pulses for 30 min. No genotoxic effects of THz radiation were observed in fibroblasts unless peak intensity and electric field strength exceeded 21 GW cm−2 and 2.8 MV cm−1, respectively. In tumor cell lines (neuroblastoma (SK-N-BE (2)) and glioblastoma (U87)), exposure to THz pulses with peak intensity of 21 GW cm−2 for 30 min caused no morphological changes as well as no statistically significant increase in histone phosphorylation foci number.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Russian Academy of Sciences, Moscow
Funding Agency		?????
Country		RUSSIAN FEDERATION
References		Sitnikov, DS et al. Biomedical Optics Express. , (2021) 12:7122-7138 Sitnikov, DS et al. J Biophotonics., (2022) E202200212:-
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