ID Number		291
Study Type		In Vitro
Model		Ultra wide band exposure to cells lines and analysis of growth and gene expression
Details		Human fetal fibroblasts (HFFF2) and rabbit corneal cells (SIRC) were exposed to 1, 2, or 3 doses of UWB RF at 4.5 kV/m (1 nano second rise time and 2170 pulses/second repetition rate) in a horn antenna and isolated 24, 48, or 72 hours post-exposure for metabolic analysis. No changes in ODC, NF-Y, NFkB / cREL, or cytokeratins 1-19 were observed by western blotting. A 3 hour exposure of UWB RF did result in a 14% & 5% decrease in cell number in HFFF2 and SIRC cultures, respectively, at 24 hours post-exposure. This decrease was associated with an increase in the percentage of G0-G1 (resting) cells. Further studies with MMC demonstrated the UWB exposure did not result in an effect on DNA repair.
Findings		Effects
Status		Completed Without Publication
Principal Investigator		Defence Evaluation and Research Agency, UK
Funding Agency		DOH, UK
Country		UNITED STATES
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