ID Number		285
Study Type		In Vivo
Model		2450 MHz (CW), UWB exposure to rats and analysis of blood pressure
Details		Wistar - Kyoto rats (male, n=38) were exposed to 2450 MHz (CW) RF for 30 minutes at 0, 0.39, 3.85, or 6.67 W/kg in a circularly polarized waveguide. Two weeks after exposures, blood pressure in the rats was measured with a sphygmomanometer equipped with a photoelectric sensor without anesthesia. In animals exposed to 0.39 W/kg, a non-statistically significant 5.6 mmHg mean decrease in systolic bp was observed, but a larger than expected probability of rats in the 0.39 W/kg exposure group were hypotensive (possibly indicating a sensitive subgroup within the exposed population. No effects were observed at 3.65 or 6.37 W/kg, which likely caused thermal levels of exposure. The authors speculate that a hypotensive effect is related to RF exposure at low SAR and short duration, and may involved interaction with the baroreceptor reflex. Preliminary orthostatic test results indicate a lack of pressor response and a lack of reflexive inhibition of the heart rate, and may support this conclusion. An earlier study using UWB exposure (PW - 85-93 kV/m, 180-200 ps rise time, 1 ns pulse width) at 70 or 120 W/kg for 6 minutes also resulted in hypotension in Wistar rats. While heart rate was not effected, bp was decreased and remained lower throughout the 4 week UWB study.
Findings		Effects
Status		Completed With Publication
Principal Investigator		USAF Research Lab, Brooks AF Base, USA - shin-tsu.lu@afrlars.brooks.af.mil
Funding Agency		AF, USA
Country		UNITED STATES
References		Lu, ST et al. Physiol. and Behav., (1999) 65:753-761
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