ICES Database ElectroMagnetic Field Literature Search Engine |
 |
| |
| Home |
| View EMF Studies (Static,ELF) 0-300 Hz |
| View EMF Studies (Intermediate) 300 Hz-300 KHz |
| View EMF Studies (RF/mmW/THz) 300 kHz-300 GHz |
| Advanced Search |
| Citation List (Author Search) |
(Database last updated on Mar 27, 2024)
| ID Number | 2841 | |
| Study Type | In Vivo | |
| Model | We investigated hepatic oxidative stress in normal and diabetic rats exposed to 900 MHz [GSM, 24 hours/day, 28 days]. | |
| Details | AUTHORS' ABSTRACT: Ismaiil et al. 2019 (IEEE #7302): The excessive exposure of patients with type 2 diabetes mellitus (T2DM) to electromagnetic radiation (EMR) from mobile phones or their base stations antenna may influence oxidative stress and development of diabetic complications. Here, we investigated the effects of exposing type 2 diabetic rats to EMR of 900 MHz emitted from GSM mobile phone antenna for 24 hours/day over a period of 28 days on hyperglycemia and hepatic oxidative stress. Male Sprague-Dawley rats were divided into 4 groups (12 rats/group): control rats, normal rats exposed to EMR, T2DM rats generated by nicotinamide/streptozotocin administration, and T2DM rats exposed to EMR. Our results showed that the exposure of T2DM rats to EMR nonsignificantly reduced the hyperglycemia and hyperinsulinemia compared to unexposed T2DM rats. The exposure of T2DM rats to EMR for 28 days increased the hepatic levels of MDA and Nrf-2 as well as the activities of superoxide dismutase (SOD) and catalase but decreased phosphorylated Akt-2 (pAkt-2) as compared to unexposed T2DM rats. Therefore, the decrease in the hepatic pAkt-2 in T2DM rats after the exposure to EMR may result in elevated level of hepatic MDA, even though the level of Nrf-2 and the activities of SOD and catalase were increased. Abbreviations: BGL: blood glucose level; EMR: electromagnetic radiation; GSM: global system for mobile communication; H2O2: hydrogen peroxide; LSD: least significance difference; MDA:malondialdehyde; Nrf-2: nuclear factor erythroid 2- related factor 2; PI3K: phosphoinositide-3-kinase; pAkt-2: phosphorylated Akt-2; Akt-2: protein kinase; ROS: reactive oxygen species; SEM: standard error of the mean; STZ: streptozotocin; SOD: superoxide dismutase ; O2-: superoxide radical; CT: threshold cycle; T2DM: type 2 diabetes mellitus. |
|
| Findings | No Effects | |
| Status | Completed With Publication | |
| Principal Investigator | Beirut Arab Univ , Beirut , Lebanon | |
| Funding Agency | ????? | |
| Country | LEBANON | |
| References |
|
|
| Comments |