ID Number		279
Study Type		Human / Provocation
Model		900 MHz (GSM) exposure to humans and analysis of hormone levels
Details		Human subjects (30 males, 20-40 yrs) were stimulated with hypo-pituitary releasing hormone injections (GnRH or LH-RH) and exposed for 1 hour (during a 2 hour hormone secretion time-course) to 900 MHz (GSM) RF by listening to movie soundtrack through a phone at peak power (2 Watts). An initial sham exposure run was performed on all subjects before each experiment. During each actual experiment, 10 of the subjects were again sham exposed and 20 subjects were exposed to RF. Hormone sampling was performed at -15, 0, 30, 60, 90, and 120 minutes. For the TRH study, TSH & PRL levels were measured. For the LH-RH study, LH & FSH levels were measured. Initial results showed no statistically significant differences in time & maximum of the peak values or area under the curve, although there was a slightly elevated TSH in some volunteers and a slight mean LH decrease in one exposure session. The authors indicated that clarification of these findings would necessitate an additional study with >300 volunteers. In subsequent studies looking at longer term exposure, human subjects (2 groups of 19 men) listened to movie soundtrack through a 900 MHz or an 1800 MHz GSM phone for 2hr/day, 5 days/wk, for 4 weeks (phone at peak power, 2 Watts). Four sampling periods (pre-exposure and 2 wks-, 4 wks-, and 6 wks-post exposure) were taken for serum melatonin, ACTH, cortisol, TSH, GH, prolactin levels. Blood samples during the 4 sampling periods were collected hourly from 10pm to 10am, and every 3 hrs from 10am to 10pm. No statistically significant change in melatonin levels (area under the curve or melatonin peak levels) was observed in either study. Melatonin peak time at 6 wks-post exposure did have increasing trend, but it was not statistically significant. A 27-29% decrease in the maximal peak GH levels with 900 MHz exposure at week 2 as well as week 4 compared to the pre-exposure levels was initially found to be statistically significant, but this was not reproduced in a subsequent (independent and non-Motorola funded) study. In addition, an initial statistically significant 21% decrease in TSH levels was initially observed, but this was not replicated in a subsequent follow up study. Some decreases in cortisol levels were also observed. The slight changes observed in hormone levels following exposure were interpreted as not physiologically significant or pathological. Subsequent studies with (n=20) exposed as above to a 900 Mhz (GSM) mobile phone while watching a movie. Calculated peak SAR in the temporal lobe of the brain was 0.3 W/kg. Hormone profile was evaluated via blood samples before, during, and after RF exposure. The authors report no significant effect of RF exposure on serum cortisol, testosterone, TSH, GH, PRL, or ACTH levels.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		University of Montpillier, France - biomed@zeus.sc.univ-montpl.fr
Funding Agency		Motorola, France Telecom/CNET, CoMoBio, France
Country		FRANCE
References		Djeridane, Y et al. Radiation Research, (2008) 169:337-343 de Seze, R et al. J Pineal Res, (1999) 27:237-242 de Seze, R et al. Bioelectromagnetics, (1998) 19:271-278
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