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(Database last updated on Mar 27, 2024)
| ID Number | 2786 | |
| Study Type | In Vivo | |
| Model | The present study aimed to examine the effects of exposure to a global system for mobile communication (GSM) with mobile phones on inhibitory avoidance (IA) memory performance as well as the involvement of endogenous opioids and nitric oxide (NO) in rats. | |
| Details | AUTHORS' ABSTRACT: Ahmadi et al. (IEEE #7063): The use of mobile phones is increasing, and the main health concern is the possible deleterious effects of radiation on brain functioning. The present study aimed to examine the effects of exposure to a global system for mobile communication (GSM) with mobile phones on inhibitory avoidance (IA) memory performance as well as the involvement of endogenous opioids and nitric oxide (NO) in this task. Male Wistar rats, 1012/weeks old, were used. The results showed that four weeks of mobile phone exposure impaired IA memory performance in rats. The results also revealed that post-training, but not pre-training, as well as pre-test intracerebroventricular (i.c.v.) injections of naloxone (0.4, 4 and 40/ng/rat), dose-dependently recovered the impairment of IA memory performance induced by GSM radiation. Additionally, the impairment of IA memory performance was completely recovered in the exposed animals with post-training treatment of naloxone (40/ng/rat) plus pre-test i.c.v. injections of L-arginine (100 and 200/nmol/rat). However, pre-test i.c.v. injections of L-NAME (10 and 20/nmol/rat), impaired IA memory performance in the animals receiving post-training naloxone (40/ng/rat). In the animals receiving post-training naloxone treatment, the impairment of IA memory performance due to pre-test i.c.v. injections of L-NAME was recovered by the pre-test co-administration of L-arginine. It was concluded that the recovery from impairment of IA memory in GSM-exposed animals with post-training naloxone treatment was the result of blockade of the opioidergic system in early memory consolidation as well as activation of the nitrergic system in the retrieval phase of memory. |
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| Findings | Effects | |
| Status | Completed With Publication | |
| Principal Investigator | ||
| Funding Agency | ????? | |
| Country | IRAN (ISLAMIC REPUBLIC OF) | |
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