ID Number		2765
Study Type		In Vivo
Model		The Ramazzini Institute (RI) performed a life-span carcinogenic study on Sprague-Dawley rats to evaluate the carcinogenic effects of RFR in the situation of far field, reproducing the environmental exposure to RFR generated by 1.8 GHz GSM antenna of the radio base stations of mobile phone.
Details		AUTHORS' ABSTRACT: Falcioni, Tibaldi, Belpoggi et al. 2018 (IEEE #6945): Background: In 2011, IARC classified radiofrequency radiation (RFR) as possible human carcinogen (Group 2B). According to IARC, animals studies, as well as epidemiological ones, showed limited evidence of carcinogenicity. In 2016, the NTP published the first results of its long-term bioassays on near field RFR, reporting increased incidence of malignant glial tumors of the brain and heart Schwannoma in rats exposed to GSM  and CDMA  modulated cell phone RFR. The tumors observed in the NTP study are of the type similar to the ones observed in some epidemiological studies of cell phone users. Objectives: The Ramazzini Institute (RI)performed a life-span carcinogenic study on Sprague-Dawley rats to evaluate the carcinogenic effects of RFR in the situation of far field, reproducing the environmental exposure to RFR generated by 1.8 GHz GSM antenna of the radio base stations of mobile phone. This is the largest long-term study ever performed in rats on the health effects of RFR, including 2448 animals. In this article, we reported the final results regarding brain and heart tumors. Methods: Male and female Sprague-Dawley rats were exposed from prenatal life until natural death to a 1.8 GHz GSM far field of 0, 5, 25, 50 V/m with a whole-body exposure for 19 h/day. Results: A statistically significant increase in the incidence of heart Schwannomas was observed in treated male rats at the highest dose (50 V/m). Furthermore, an increase in the incidence of heart Schwann cells hyperplasia was observed in treated male and female rats at the highest dose (50 V/m), although this was not statistically significant. An increase in the incidence of malignant glial tumors was observed in treated female rats at the highest dose (50 V/m), although not statistically significant. Conclusions: The RI findings on far field exposure to RFR are consistent with and reinforce the results of the NTP study on near field exposure, as both reported an increase in the incidence of tumors of the brain and heart in RFR-exposed Sprague-Dawley rats. These tumors are of the same histotype of those observed in some epidemiological studies on cell phone users. These experimental studies provide sufficient evidence to call for the reevaluation of IARC conclusions regarding the carcinogenic potential of RFR in humans. ENVIRONMENTAL RESEARCH Journal withdraws above paper on March 7, 2018: "Withdrawn Article in Press  Note to users" " Withdrawn Articles in Press are proofs of articles which have been peer reviewed and initially accepted, but have since been withdrawn before being published in this publication. Reasons for withdrawal may be a decision by the author and/or editor, accidental duplication of an article elsewhere or because the content contravenes the Elsevier publishing policy in some way. Withdrawn Articles in Press are only visible to users when following an external link, e.g., a PubMed or DOI link. Such Withdrawn Articles in Press are not searchable or otherwise available in ScienceDirect."
Findings		Effects
Status		Completed With Publication
Principal Investigator		Ramazzini Institute, Bologna, Italy
Funding Agency		Ramazzini Institute
Country		ITALY
References		Falcioni, L et al. Environmental Research. , (2018) 165:496-503 Falcioni, L et al. Environmental Research., (2018) Online March 7:-(1 page) Vornoli, A et al. Int J Environ Res Public Health. , (2019) 16:3379-(27 pages) Belpoggi, F et al. Environmental research., (2021) 197:111067-
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