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(Database last updated on Mar 27, 2024)
| ID Number | 2638 | |
| Study Type | In Vivo | |
| Model | We investigated the thermal effects of RF fields on the variation in core temperature and gene expression of some stress markers in rats exposed to 2.14 GHz (W-CDMA) at a whole-body averaged SAR) of 4 and 0.4 W/kg and 21 kHz (3.8 mT) fields on brain biomarkers in mice. | |
| Details | AUTHORS' ABSTRACT: Ohtani et al. 2016 (IEEE #6495): We investigated the thermal effects of radiofrequency electromagnetic fields (RF-EMFs) on the variation in core temperature and gene expression of some stress markers in rats. Sprague-Dawley rats were exposed to 2.14 GHz wideband code division multiple access (W-CDMA) RF signals at a whole-body averaged specific absorption rate (WBA-SAR) of 4 W/kg, which causes behavioral disruption in laboratory animals, and 0.4 W/kg, which is the limit for the occupational exposure set by the International Commission on Non-Ionizing Radiation Protection guideline. It is important to understand the possible in vivo effects derived from RF-EMF exposures at these intensities. Because of inadequate data on real-time core temperature analyses using free-moving animal and the association between stress and thermal effects of RF-EMF exposure, we analyzed the core body temperature under nonanesthetic condition during RF-EMF exposure. The results revealed that the core temperature increased by approximately 1.5°C compared with the baseline and reached a plateau till the end of RF-EMF exposure. Furthermore, we analyzed the gene expression of heat-shock proteins (Hsp) and heat-shock transcription factors (Hsf) family after RF-EMF exposure. At WBA-SAR of 4 W/kg, some Hsp and Hsf gene expression levels were significantly upregulated in the cerebral cortex and cerebellum following exposure for 6 hr/day but were not upregulated after exposure for 3 hr/day. On the other hand, there was no significant change in the core temperature and gene expression at WBA-SAR of 0.4 W/kg. Thus, 2.14-GHz RF-EMF exposure at WBA-SAR of 4 W/kg induced increases in the core temperature and upregulation of some stress markers, particularly in the cerebellum. |
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| Findings | Effects | |
| Status | Completed With Publication | |
| Principal Investigator | Meiji Pharmaceutical Univ, Tokyo, Japan. | |
| Funding Agency | ????? | |
| Country | JAPAN | |
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