ID Number		262
Study Type		In Vivo
Model		2450 MHz (CW, AM-50 Hz) exposure to mice and analysis of immune parameters
Details		Balb-C mice were exposed for six subsequent days for one and half, three, six or twelve hours per day with average power density 0.1 mW cm-2 , and whole body SAR 0.l4l W kg-1 (50 Hz amplitude-modulated (AM) 2.45 GHz). Mice were immunised on the second day of exposure with sheep red blood cells. Mice were bled on the 5th day of the immune response. Body mass, spleen weight, spleen index, number of spleen cells, number of antibody producing cells (PFC) and IgG level were measured. Chronic (cw) exposures (6 d, 3 h d-1) induced elevations (+37%) of the number of antibody producing cells in the spleen of male mice. AM microwave radiation exposures induced elevation of the spleen index (+15%) and antibody producing cell number (+56%) in the spleen of male mice. No elevations were observed in female mice. In female mice, 1.5 h AM exposures significantly depressed spleen weight and the number of spleen cells and 12 h exposures nearly significantly depressed the number of spleen cells and the number of antibody producing cells. Serum hemagglutinin titre was not altered by the exposure. Both CW and AM exposure for 6 h d-1 significantly elevated hemolysin titer in male mice. In female mice after 1.5 h exposure a significant depression occurred. The IgG level was not altered.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Res. Inst. for Radiobiol & Radiohyg, Hungary - thuroczy@hp.osski.hu
Funding Agency		Ministry of Welfare, Hungary
Country		HUNGARY
References		Elekes, E et al. Bioelectromagnetics, (1996) 17:246-248
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