ID Number		2612
Study Type		In Vitro
Model		Embryonic development up to the blastocyst stage was studied in mouse embryos (2-cell stage) for 4 days (30 min/d) and effects on human sperm exposed in vitro to cell phone emissions.
Details		AUTHOR'S ABSTRACT: Safian et al. 2016 (IEEE #6426): BACKGROUND: Using cellular phone has rapidly increased all over the world. Also, the concern on the possible health hazards of electromagnetic fields (EMF) induced from cell phones to reproduction has been growing in many countries. The aim of this study was to assess the consequences and effects of exposure to the cell phone radiation on the quality and survival rates of preimplantation embryos in mice. METHODS: A total of 40 mice (20 females and 20 males), 6 weeks old and sexually mature BALB/c, were used for control and experimental groups. The ovary burses were removed and the zygotes were dissected in the morning after mating. Next, 2-cell embryos were divided into two groups of control (n=150) and experimental (n=150). EMF (900-1800 MHz) was used for four days in experimental group for 30 min/day in culture at 37°C in a CO 2 incubator. The quality of embryos was recorded daily and the fluorescent staining was used for identification of viable blastocysts. All data were compared by Student's t-test and Mann-Whitney test (p<0.05). RESULTS: The rate of embryo survival to the blastocysts stage was similar in both groups. However, the percentage of dead embryos at the 2-cell stage was significantly higher in EMF-exposed group compared with controls (p=0.03). Also, the loss of cell viability significantly increased in experimental blastocysts (p=0.002). CONCLUSION: The normal embryonic development up to the blastocyst stage indicates that EMF-exposure commonly did not have adverse effect on embryo development in mice. But, it caused loss of blastocysts cell viability.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Shahid Sadoughi U of Med Scien, Yazd, Iran
Funding Agency		?????
Country		IRAN (ISLAMIC REPUBLIC OF)
References		Safian, F et al. J Reprod Infertil., (2016) 17:138-143 Hassanzadeh-Taheri, M et al. Andrologia. , (2022) 54:e14257- Mahaldashtian, M et al. Zygote., (2022) 30:176-182
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