ID Number		26
Study Type		In Vivo
Model		2450 MHz exposure to rats and analysis of cancer and pathology (2-year bioassay)
Details		Sprague Dawley rats (male, n=200) were exposed to 2450 MHz (PW-800 pps, 10-usec pulse width, square-wave modulated at 8 Hz) microwaves at whole body average SARs from 0.4 W/kg (for a 200-g rat) to 0.15 W/kg (for an 800-g rat) in circular waveguides (Guy et al. Radio Sci 14:63-74, 1979). Exposure began at 8 wk of age and continued daily 21.5 hr/day, 5 days/wk, for 25 months. An initial change in corticosterone levels and immune function seen at 13 months could not be replicated in a repeat study. There was no change in open field behavior, immune function, ematological, serum chemistry, thyroxine, or protein parameters, metabolism, growth or behavior. There was no increase in any tumor type [although there were 7 pheochromocytoma tumors in the exposed group vs 1 in the controls], although a statistically significant ~4-fold increase in total primary malignant tumors in exposed vs sham exposed animals (18 in exposed vs 5 in controls) was observed. The authors did not interpret these observations as biologically significant due to the lack of an increase in any one tumor type and the lack of a difference in the number of benign neoplasms between the groups at death (39 in exposed, 38 in controls).
Findings		Effects
Status		Completed With Publication
Principal Investigator		Motorola Labs, Ft. Lauderdale FL, USA
Funding Agency		AF, USA
Country		UNITED STATES
References		Chou, CK et al. Bioelectromagnetics, (1992) 13:469-496 Chou, CK et al. Bioelectromagnetics, (1984) 5:389-398 Guy, AW et al. EFFECTS OF LONG-TERM LOW-LEVEL RADIOFREQUENCY RADIATION EXPOSURE ON RATS: VOLUME 1. DESIGN, FACILITIES, AND PROCEDURES, (1983) :- Guy, AW et al. EFFECTS OF LONG-TERM LOW-LEVEL RADIOFREQUENCY RADIATION EXPOSURE ON RATS: VOLUME 2. AVERAGE SAR AND SAR DISTRIBUTION IN MAN EXPOSED TO 450-MHz RFR, (1983) :- Guy, AW et al. EFFECTS OF LONG-TERM LOW-LEVEL RADIOFREQUENCY RADIATION EXPOSURE ON RATS: VOLUME 9. SUMMARY, (1985) :- Johnson, RB et al. EFFECTS OF LONG-TERM LOW-LEVEL RADIOFREQUENCY RADIATION EXPOSURE ON RATS: VOLUME 4. OPEN-FIELD BEHAVIOR AND CORTICOSTERONE, (1983) :- Johnson, RB et al. EFFECTS OF LONG-TERM LOW-LEVEL RADIOFREQUENCY RADIATION EXPOSURE ON RATS: VOLUME 7. METABOLISM, GROWTH, AND DEVELOPMENT, (1984) :- Kunz, LL et al. EFFECTS OF LONG-TERM LOW-LEVEL RADIOFREQUENCY RADIATION EXPOSURE ON RATS: VOLUME 5. EVALUATION OF THE IMMUNE SYSTEM'S RESPONSE, (1983) :- Kunz, LL et al. EFFECTS OF LONG-TERM LOW-LEVEL RADIOFREQUENCY RADIATION EXPOSURE ON RATS: VOLUME 6. HEMATOLOGICAL, SERUM CHEMISTRY, THYROXINE, AND PROTEIN ELECTROPHORESIS EVALUATIONS, (1984) :- Kunz, LL et al. EFFECTS OF LONG-TERM LOW-LEVEL RADIOFREQUENCY RADIATION EXPOSURE ON RATS: VOLUME 8. EVALUATION OF LONGEVITY, CAUSE OF DEATH, AND HISTOPATHOLOGICAL FINDINGS, (1985) :- Chou, CK et al. Report, (1983) :-
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