ID Number		2599
Study Type		In Vivo
Model		The brains of mice exposed at 835 MHz (4 W/kg) for 5 h/d for 4 and 12 weeks were examined for autophagy, gene expression, protein expression and by electron microscopy.
Details		AUTHORS' ABSTRACT: Kim, Huh and Kim 2016 (IEEE #6394): The extensive use of wireless mobile phones and associated communication devices has led to increasing public concern about potential biological health-related effects of the exposure to electromagnetic fields (EMFs). EMFs emitted by a mobile phone have been suggested to influence neuronal functions in the brain and affect behavior. However, the affects and phenotype of EMFs exposure are unclear. We applied radiofrequency (RF) of 835 MHz at a specific absorption rate (SAR) of 4.0 W/kg for 5 hours/day for 4 and 12 weeks to clarify the biological effects on mouse brain. Interestingly, microarray data indicated that a variety of autophagic related genes showed fold-change within small range after 835 MHz RF exposure. qRT-PCR revealed significant up-regulation of the autophagic genes Atg5, LC3A and LC3B in the striatum and hypothalamus after a 12-week RF. In parallel, protein expression of LC3B-II was also increased in both brain regions. Autophagosomes were observed in the striatum and hypothalamus of RF-exposed mice, based on neuronal transmission electron microscopy. Taken together, the results indicate that RF exposure of the brain can induce autophagy in neuronal tissues, providing insight into the protective mechanism or adaptation to RF stress.
Findings		Effects
Status		Completed With Publication
Principal Investigator
Funding Agency		?????
Country		KOREA, REPUBLIC OF
References		Kim, JH et al. PLOS ONE., (2016) 11(4):e0153308. doi:10.1371/journal.-
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