ID Number		2561
Study Type		In Vivo
Model		Reports from the Ramazzini Institute (Italy) describing long-term cancer studies of rodents exposed to RF signals and 50 Hz fields.
Details		AUTHORS' ABSTRACT: Soffritti et al. 2016 (IEEE #6308): Background In 2002 the International Agency for Research on Cancer classified extremely low frequency magnetic fields (ELFMF) as a possible carcinogen on the basis of epidemiological evidence. Experimental bioassays on rats and mice performed up to now on ELFMF alone or in association with known carcinogens have failed to provide conclusive confirmation. Objectives To study the carcinogenic effects of combined exposure to sinusoidal-50 Hz (S-50Hz) magnetic fields and acute gamma-radiation in Sprague-Dawley rats. Methods We studied groups of male and female Sprague-Dawley rats exposed from prenatal life until natural death to 20 or 1000 microT S-50Hz MF and also to 0.1 Gy gamma-radiation delivered as a single acute exposure at 6 weeks of age. Results The results of the study showed significant carcinogenic effects for the mammary gland in males and females and a significant increased incidence of malignant schwannomas of the heart as well as increased incidence of lymphomas/leukemias in males. Conclusions These results call for a re-evaluation of the safety of non-ionizing radiation. AUTHORS' ABSTRACT: Soffritti et al. 2010 (IEEE #6379): In 2002 Ramazzini Institute launched an experimental research project to evaluate the potential carcinogenic effects of power frequency magnetic fields in Sprague- Dawley rats exposed from prenatallife until spontaneous death to sinusoidal S0 Hzmagnetic fields (S-50H" Am) at various intensity levels, or in association with other agents. For this objective, 4 experiments were planned as an integrated experimental project aiming to: 1) assess the qualitative- quantitative potential carcinogenic effects on S-50H2 MF in various different exposure situations, with reference to intensity and continnity/discontinuity of the electrie current; 2) evaluate the effects on reproductivity and emtrryo/fetus toxicity of S-50H2 MF; 3) assess the syncarcinogenic effects of S-50IIz MF and other electromagnetic fields (y-radiation); 4) assess the syncarcinogenic effects of S-50H2 MF and carcinogenic chemical agents such as formaldehyde and Aflatoxin 81; I evaluate, by molecular biology analysis, the possible pathogenic mechanisms at the basis of carcinogenesis. In the research project are included the evaluation of2,100 breeders and 7,133 offspring. In the present report will be illustrate the design of the glotral project and the first result concerning the carcinogenic e{fects to the mammary gland in females exposed to S-50H2 MF from fetal life until death as well as to 10 rads pradiafion delivered in one shot at 6 weeks of age. AUTHORS' ABSTRACT: Soffritti and Giuliani 2019 (IEEE #7171): Epidemiological studies have suggested that human exposure to extremely low-frequency electromagnetic fields from the electric power and to mobile phone radiofrequency electromagnetic fields induce an increased risk of developing malignant tumours. However, no adequate laboratory data, in particular long-term carcinogenicity bioassays to support the epidemiological evidence, have yet been available. This motivated the Ramazzini Institute to embark on a first project of four large life-span carcinogenic bioassays conducted on over 7000 Sprague Dawley rats exposed from prenatal life until natural death to S-50 Hz MF alone or combined with gamma radiation or formaldehyde or aflatoxin B1. Results now available from these studies, which started concurrently, have shown that exposure to Sinusoidal-50 Hz Magnetic Field (S-50 Hz MF) combined with acute exposure to gamma radiation or to chronic administration of formaldehyde in drinking water induces a significantly increased incidence of malignant tumours in males and females. A second project of two large life-span carcinogenic bioassays was conducted on over 3000 Sprague Dawley rats exposed from prenatal life until natural death to 1.8 GHz GSM of mobile phone radio base station, alone or combined with acute exposure to gamma radiation. Early results from the experiment on 1.8 GHz GSM alone show a statistically significant increase in the incidence of heart malignant schwannoma among males exposed at the highest dose.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Ramazzini Institute, Bologna, italy
Funding Agency		?????
Country		ITALY
References		Soffritti, M et al. International Journal of Radiation Biology., (2016) 92:202-214 Soffritti, M et al. Eur. J. Oncol. Library., (2010) 5:219-234 Soffritti, M et al. Basic Clin Pharmacol Toxicol., (2019) 00:1-12 Soffritti, M et al. Am J Ind Med., (2016) 59:509-521
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