ID Number		2542
Study Type		In Vivo
Model		Urine of rats exposed (1 W/kg, 2 h) to GSM signals were assayed for 8-oxodG, a biomarker of DNA damage.
Details		AUTHORS' ABSTRACT: Khalil et al. 2012 (IEEE #6235): We examined the effect of exposure to mobile phone 1800 MHz radio frequency radiation (RFR) upon the urinary excretion of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG), one major form of oxidative DNA damage, in adult male Sprague-Dawley rats. Twenty-four rats were used in three independent experiments (RFR exposed and control, 12 rats, each). The animals were exposed to RFR for 2 h from Global System for Mobile Communications (GSM) signal generator with whole-body-specific absorption rate of 1.0 W/kg. Urine samples were collected from the rat while housed in a metabolic cage during the exposure period over a 4-h period at 0.5, 1.0, 2.0 and 4.0 h from the beginning of exposure. In the control group, the signal generator was left in the turn-off position. The creatinine-standardized concentrations of 8-oxodG were measured. With the exception of the urine collected in the last half an hour of exposure, significant elevations were noticed in the levels of 8-oxodG in urine samples from rats exposed to RFR when compared to control animals. Significant differences were seen overall across time points of urine collection with a maximum at 1 h after exposure, suggesting repair of the DNA lesions leading to 8-oxodG formation.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Yarmouk University, Jordan
Funding Agency		?????
Country		SAUDI ARABIA
References		Khalil, AM et al. Hum Exp Toxicol., (2012) 31:734-740
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