ID Number		2489
Study Type		In Vivo
Model		Rabbit femurs with metal implants were exposed to 2450 MHz at 20-80W for 30 min and temperatures of the implants and adjacent muscles were recorded; to evaluate thermal damage, nerves were electrodiagnostically assessed immediately after exposure and histologic studies were performed on nerve and muscle samples.
Details		AUTHORS' ABSTRACT: Ye et al. 2015 (IEEE #6006): This study aimed to examine the safety profile of microwave therapy on limbs with metal implants. New Zealand white rabbits were implanted with titanium alloy internal fixation plates. Femurs were exposed to 20, 40, 60, or 80W of microwave radiation for 30 min (microwave applicator at 2450 MHz), and temperatures of the implants and muscles adjacent to implants were recorded. To evaluate thermal damage, nerves were electrodiagnostically assessed immediately after radiation, and histologic studies performed on nerve and muscle sections. As expected, implant temperature was highest in the exposure field. Temperatures of limbs with titanium alloy implants increased significantly at 60 and 80W, with a significant decline in the nerve conduction velocity and acute thermal injuries in nerves and muscles adjacent to implants. However, temperature remained unchanged and no adverse effects were observed in nerves and muscles at 20 and 40W. These findings are inconsistent with the current notion that surgical metal implants in the treatment field are contraindications for microwave therapy. Hence, we believe that a lower dose of continuous wave microwave irradiation is safe for limbs with titanium alloy implants.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Shanghai JiaoTong U. Shanghai, China
Funding Agency		?????
Country		CHINA
References		Ye, D et al. Bioelectromagnetics. , (2015) 36:309-318
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