ID Number		2464
Study Type		In Vitro
Model		Bone marrow mesenchymal stem cells (MSCs) proliferation, apoptosis, cell cycle, and differentiation were assayed following 2.856 GHz microwave exposure in vitro at 4 W/kg.
Details		AUTHORS' ABSTRACT: Wang et al. 2015 (IEEE #5940): The increasing use of microwave devices over recent years has meant the bioeffects of microwave exposure have been widely investigated and reported. However the exact biological fate of bone marrow MSCs (BM-MSCs) after microwave radiation remains unknown. In this study, the potential cytotoxicity on MSC proliferation, apoptosis, cell cycle, and in vitro differentiation were assayed following 2.856 GHz microwave exposure at a specific absorption rate (SAR) of 4 W/kg. Importantly, our findings indicated no significant changes in cell viability, cell division and apoptosis after microwave treatment. Furthermore, we detected no significant effects on the differentiation ability of these cells in vitro, with the exception of reduction in mRNA expression levels of osteopontin (OPN) and osteocalcin (OCN). These findings suggest that microwave treatment at a SAR of 4 W/kg has undefined adverse effects on BM-MSCs. However, the reduced-expression of proteins related to osteogenic differentiation suggests that microwave can the influence at the mRNA expression genetic level.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Beijing Institute of Radiation Medicine, Beijing,
Funding Agency		?????
Country		CHINA
References		Wang, C et al. PLoS ONE., (2015) 10(2): e0117550.:-
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