ID Number		244
Study Type		In Vivo
Model		900, 1800 MHz (GSM) exposure to B6C3F1 mice and analysis of cancer (2-yr bioassay)
Details		B6C3F1 mice (n = 1170 total, 130 per exposure group, half males half females) were exposed to 900 and 1800 MHz (GSM) RF 2 hours/day, 5 days/week, for 24 months in an NTP-like carcinogenicity bioassay. The target SAR [whole body] for 900 MHz exposure was 0, 0.44, 1.33, 4.0 W/kg, and for 1800 MHz exposure was 0, 0.33, 1.0, and 3.0 W/kg. RF signal included a cocktail of all components commonly existing in a standard mobile phone transmission (i.e., low-frequency amplitude modulation resulting from speaking, delayed transmissions associated with listening, variations due to handovers and power control). Mice were tube-restrained and radially positioned in a ferris-wheel system with a central antenna. Dosimetry and numerical modeling revealed generally homogeneous exposure. The study included cage control animals as well as sham and three RF exposed groups. The GLP animal study was conducted blind. The authors report no effects on tumors or on average body weight, weight gain curves, ratio of polychromatic red blood cells or other blood and tissue parameters(peripheral blood and bone marrow erythrocytes, keratinocytes, and spleen lymphocytes). There was a slight dose dependent decrease in hepatocellular carcinoma, but not statistically significant.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Fraunhofer ITEM, Hannover, Germany - dasenbrock@ita.fhg.de
Funding Agency		EU, MMF, GSM Association, Perform A, EU 5th Framework, Europe
Country		GERMANY
References		Tillmann, T et al. Bioelectromagnetics., (2007) 28:173-187 Tillmann , T et al. Int J Radiat Biol., (2010) 86(7):529-541
Comments		The project is part of the EU research project PERFORM-A.