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(Database last updated on Mar 27, 2024)
| ID Number | 2430 | |
| Study Type | In Vivo | |
| Model | Studies on behavior and the brain of animals (rats and mice) exposed (whole-body) to RF fields [848.5 MHz (CDMA), 915 MHz (RFID) and 1950 MHz]. | |
| Details | AUTHORS' ABSTRACT: Kim et al. 2015 (IEEE #5823): Introduction: Whether exposure to the 848.5 MHz code division multiple access (CDMA) signal affects adult neurogenesis is unclear. Materials and methods: An animal experiment was performed with a reverberation chamber designed as a whole-body CDMA exposure system. Male Sprague-Dawley rats were assigned to three groups (n = 6 per group): Cage-control, sham-exposed, and CDMA-exposed groups. Rats in the CDMA-exposed group were exposed to the CDMA signal at a 2 W/kg whole-body specific absorption rate (SAR) for 1 or 8 h daily, 5 days per week, for 2 weeks. Rats received a single intraperitoneal injection of Bromodeoxyuridine (BrdU) to label proliferative cells daily for the last five consecutive days of CDMA signal exposure. An unbiased stereological method was used to estimate the number of BrdU+ cells in the subventricular zone (SVZ) and dentate gyrus (DG). Results: We found no significant changes in the number of BrdU+ cells in the SVZ or DG in the CDMA-exposed rats, compared with rats in the cage-control and sham-exposed groups (p > 0.05). Conclusion: Our results suggest that exposure to the CDMA signal does not affect neurogenesis in the adult rat brain, at least under our experimental conditions. AUTHORS' ABSTRACT: Kim et al. 2015 (IEEE #6135): To explore the effects of radiofrequency electromagnetic field on the fate of neuronal cells, we investigated whether exposure to 915 MHz radiofrequency identification (RFID) caused morphological changes in neuronal cells in rat hippocampal dentate gyrus (DG). A reverberation chamber was used as a whole-body RFID exposure system. Rats were assigned to two groups: sham- and RFID-exposed groups. Rats in the RFID-exposed group were exposed to RFID at 4 W/kg specific absorption rate (SAR) for 8 hours daily, 5 days per week, for 2 weeks. Morphological evaluation of DG was performed using immunohistochemistry with doublecortin (DCX) as a neuronal precursor cell marker and neuronal nuclei (NeuN) as a mature neuronal cell marker. No significant morphological changes in DCX+ or NeuN+ cells in the DG of RFID-exposed rats were observed. These results suggest that RFID exposure induces no significant change in DCX+ neuronal precursor or NeuN+ neuronal cells in DG of rats. AUTHORS' ABSTRACT: Son et al. 2015 (IEEE #6136): The increasing use of mobile phones has raised public concern about the possible biological effects of radiofrequency electromagnetic field (RF-EMF) exposure on the human brain. To investigate the potential effect of RF-EMF exposure on the brain, we examined the behaviors and hippocampal morphology of C57BL/6 mice after sub-chronic exposure to RF-EMFs with a relatively high SAR level (5.0 W/kg). We applied a 2-hour daily exposure of WCDMA 1,950 MHz using a reverberation chamber that was designed for whole-body exposure for 60 days. In the behavioral tests, RF-EMF did not alter the physical activity or long-term memory of mice. Moreover, no alteration was found in the neuronal and glial cells in the hippocampus by RF-EMFs. In this study, we showed that sub-chronic whole body RF exposure did not produce memory impairment and hippocampal morphological alteration in C57BL/6 mice. AUTHORS' ABSTRACT: Kim et al. 2015 (IEEE #6137): PURPOSE: We investigated the effects of whole-body exposure to the 915 MHz radiofrequency identification (RFID) on melatonin biosynthesis and the activity of rat pineal arylalkylamine N-acetyltransferase (AANAT). MATERIALS AND METHODS: Rats were exposed to RFID (whole-body specific absorption rate, 4 W/kg) for 8 h/day, 5 days/week, for 2 weeks during the nighttime. Total volume of urine excreted during a 24-hour period was collected after RFID exposure. Urinary melatonin and 6-hydroxymelatonin sulfate (6-OHMS) was measured by gas chromatography-mass spectrometry (GC-MS) and enzyme-linked immunosorbent assay (ELISA), respectively. AANAT enzyme activity was measured using liquid biphasic diffusion assay. Protein levels and mRNA expression of AANAT was measured by Western blot and reverse transcription polymerase chain reaction (RT-PCR) analysis, respectively. RESULTS: Eight hours of nocturnal RFID exposure caused a significant reduction in both urinary melatonin (P = 0.003) and 6-OHMS (P = 0.026). Activity, protein levels, and mRNA expression of AANAT were suppressed by exposure to RFID (P < 0.05). CONCLUSIONS: Our results suggest that nocturnal RFID exposure can cause reductions in the levels of both urinary melatonin and 6-OHMS, possibly due to decreased melatonin biosynthesis via suppression of Aanat gene transcription in the rat pineal gland. |
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| Findings | No Effects | |
| Status | Completed With Publication | |
| Principal Investigator | Ajou U Sch of Med, Suwon, South Korea. | |
| Funding Agency | ????? | |
| Country | KOREA, REPUBLIC OF | |
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