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(Database last updated on Mar 27, 2024)
| ID Number | 2417 | |
| Study Type | In Vivo | |
| Model | Free radicals/reactive oxygen species and oxidative damage to DNA were analyzed in Japanese quail embryos exposed in ovo to low intensity 900 MHz fields. | |
| Details | AUTHORS' ABSTRACT: Burlaka et al. 2013 (IEEE #5758): AIM: Long-term exposure of humans to low intensity radiofrequency electromagnetic radiation (RF-EMR) leads to a statistically significant increase in tumor incidence. Mechanisms of such the effects are unclear, but features of oxidative stress in living cells under RF-EMR exposure were previously reported. Our study aims to assess a production of initial free radical species, which lead to oxidative stress in the cell. MATERIALS AND METHODS: Embryos of Japanese quails were exposed in ovo to extremely low intensity RF-EMR of GSM 900 MHz (0.25 µW/cm2) during 158-360 h discontinuously (48 c - ON, 12 c - OFF) before and in the initial stages of development. The levels of superoxide (O2·-), nitrogen oxide (NO·), thiobarbituric acid reactive substances (TBARS), 8-oxo-2'-deoxyguanosine (8-oxo-dG) and antioxidant enzymes' activities were assessed in cells/tissues of 38-h, 5- and 10-day RF-EMR exposed and unexposed embryos. RESULTS: The exposure resulted in a significant persistent overproduction of superoxide and nitrogen oxide in embryo cells during all period of analyses. As a result, significantly increased levels of TBARS and 8-oxo-dG followed by significantly decreased levels of superoxide dismutase and catalase activities were developed in the exposed embryo cells. CONCLUSION: Exposure of developing quail embryos to extremely low intensity RF-EMR of GSM 900 MHz during at least one hundred and fifty-eight hours leads to a significant overproduction of free radicals/reactive oxygen species and oxidative damage of DNA in embryo cells. These oxidative changes may lead to pathologies up to oncogenic transformation of cells. |
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| Findings | Effects | |
| Status | Completed With Publication | |
| Principal Investigator | NAS of Ukraine, Kyiv, Ukraine. | |
| Funding Agency | ????? | |
| Country | UKRAINE | |
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