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EMF Study
(Database last updated on Mar 27, 2024)
ID Number |
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2400 |
Study Type |
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In Vivo |
Model |
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In vitro cultured cortical neuronal cells and in vivo rats brain were exposed to EMF fields to investigate the effect of mobile phone emissions on the rat central nervous system (CNS). |
Details |
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AUTHORS' ABSTRACT: Zhu et al. 2008 (IEEE #5708): To investigate the effect of microwave emitted by mobile phones on the rat central nervous system (CNS), in vitro cultured cortical neuronal cells and in vivo rats brain were exposed to the electromagnetic waves emitted by a microwave transmitter that mimics the working frequency of mobile phones. Trypan blue staining and terminal deoxynucleotidy transferase-mediated dUTP
nick-end labeling (TUNEL) were used to determine the survival state of neuronal cells while immunohistochemistry method was used to
determine the expression level of Bcl-2 and Bax. Our results show that microwave lead to significant cell death in culture and more
in vivo brain neuronal cells were stained positive for TUNEL, Bax and Bcl-2 in rats with cranial defect after exposure than that forcontrol groups (with intact cranium, or had no microwave exposure) (P < 0.01). However, no significant differences were observed in the
ratio of Bax/Bcl-2 among the groups studied. Therefore, microwave emitted from mobile phones is harmful to both in vitro cultured cortical
cells and in vivo brain neuronal cells from rat with cranial defect. The integrity of cranium is important in protecting the CNS against
apoptotic injuries inflicted by the microwaves from mobile phones. |
Findings |
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Effects |
Status |
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Completed With Publication |
Principal Investigator |
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Zhejiang Univ School of Med, Zhejiang, China
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Funding Agency |
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Chinese National Science Foundation
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Country |
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CHINA |
References |
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Zhu, Y et al. Progress In Electromagnetics Research., (2008) 82:287-298
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