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(Database last updated on Mar 27, 2024)
| ID Number | 2365 | |
| Study Type | In Vivo | |
| Model | In vivo study of microwave-induced survival adaptive responses after exposure to lethal doses of gamma radiation and other agents. | |
| Details | AUTHORS' ABSTRACT: Mortazavi et al. 2012 (IEEE #5503): The aim of this study was to investigate the effect of pre-irradiation with microwaves on the induction of radioadaptive response. In the 1(st) phase of the study, 110 male mice were divided into 8 groups. The animals in these groups were exposed/sham-exposed to microwave, low dose rate gamma or both for 5 days. On day six, the animals were exposed to a lethal dose (LD). In the 2(nd) phase, 30 male rats were divided into 2 groups of 15 animals. The 1(st) group received microwave exposure. The 2(nd) group (controls) received the same LD but there was no treatment before the LD. On day 5, all animals were whole-body irradiated with the LD. Statistically significant differences between the survival rate of the mice only exposed to lethal dose of gamma radiation before irradiation with a lethal dose of gamma radiation with those of the animals pre-exposed to either microwave (p=0.02), low dose rate gamma (p=0.001) or both of these physical adapting doses (p=0.003) were observed. Likewise, a statistically significant difference between survival rates of the rats in control and test groups was observed. Altogether, these experiments showed that exposure to microwave radiation may induce a significant survival adaptive response. AUTHORS' ABSTRACT: Mortazavi et al. 2013 (IEEE #5544): Substantial evidence indicates that adaptive response induced by low doses of ionizing radiation can result in resistance to the damage caused by a subsequently high-dose radiation or cause cross-resistance to other non-radiation stressors. Adaptive response contradicts the linear-non-threshold (LNT) dose-response model for ionizing radiation. We have previously reported that exposure of laboratory animals to radiofrequency radiation can induce a survival adaptive response. Furthermore, we have indicated that pre-exposure of mice to radiofrequency radiation emitted by a GSM mobile phone increased their resistance to a subsequent Escherichia coli infection. In this study, the survival rates in animals receiving both adapting (radiofrequency) and challenge dose (bacteria) and the animals receiving only the challenge dose (bacteria) were 56% and 20%, respectively. In this light, our findings contribute to the assumption that radiofrequency-induced adaptive response can be used as an efficient method for decreasing the risk of infection in immunosuppressed irradiated individuals. The implication of this phenomenon in humans long term stay in the space is also discussed. AUTHORS' ABSTRACT: Taheri, Mortazavi et al. 2015 (IEEE #6150): |
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| Findings | Effects | |
| Status | Completed With Publication | |
| Principal Investigator | Rafsanjan Univ Med Sci, Iran | |
| Funding Agency | ????? | |
| Country | IRAN (ISLAMIC REPUBLIC OF) | |
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