ID Number		2348
Study Type		Epidemiology
Model		Two meta-analyses of studies on intracranial tumors and mobile phone and WHO systematic review protocol for cancer risk.
Details		AUTHORS' ABSTRACT: Lagorio and 2014 (IEEE #5430): A meta-analysis of studies on intracranial tumors and mobile phone use published by the end of 2012 was performed to evaluate the overall consistency of findings, assess the sensitivity of results to changes in the dataset, and try to detect the sources of between-study heterogeneity. Twenty-nine papers met our inclusion criteria. These papers reported on 47 eligible studies (17 on glioma, 15 on meningioma, 15 on acoustic neuroma), consisting of either primary investigations or pooled analyses. Five combinations of non-overlapping studies per outcome were identified. The combined relative risks (cRRs) in long-term mobile phone users ( 10 years) ranged between 0.98 (0.751.28) and 1.11 (0.861.44) for meningioma, with little heterogeneity across studies. High heterogeneity was detected across estimates of glioma and acoustic neuroma risk in long term users, with cRRs ranging between 1.19 (95% CI 0.861.64) and 1.40 (0.962.04), and from 1.14 (0.651.99) to 1.33 (0.652.73), respectively. A meta-regression of primary studies showed that the methodological differences embedded in the variable studygroup explained most of the overall heterogeneity in results. Summary risk estimates based on heterogeneous findings should not be over-interpreted. Overall, the results of our study detract from the hypothesis that mobile phone use affects the occurrence of intracranial tumors. However, reproducibility (or lack of) is just one clue in the critical appraisal of epidemiological evidence. Based on other considerations, such as the limited knowledge currently available on risk beyond 15 years from first exposure, or following mobile phone use started in childhood, the pursuance of epidemiological surveillance is warranted. AUTHORS' ABSTRACT: Röösli, Logario et al. 2019 (IEEE #6958): Mobile phones (MPs) are the most relevant source of radiofrequency electromagnetic field (RF-EMF) exposure to the brain and the salivary gland. Whether this exposure implies a cancer risk has been addressed in several case-control and few cohort studies. A meta-analysis of these studies does not show increased risks for meningioma, pituitary, and salivary gland tumors. For glioma and acoustic neuroma, the results are heterogeneous, with few case-control studies reporting substantially increased risks. However, these elevated risks are not coherent with observed incidence time trends, which are considered informative for this specific topic owing to the steep increase in MP use, the availability of virtually complete cancer registry data from many countries, and the limited number of known competing environmental risk factors. In conclusion, epidemiological studies do not suggest increased brain or salivary gland tumor risk with MP use, although some uncertainty remains regarding long latency periods (>15 years), rare brain tumor subtypes, andMPusage during childhood.
Findings		No Effects
Status		Completed With Publication
Principal Investigator
Funding Agency		?????
Country		ITALY
References		Lagorio, S et al. Bioelectromagnetics., (2014) 35:79-90 Röösli, M et al. Annual Review of Public Health., (2019) 40:221-238 Lagorio, S et al. Environ Int., (2021) 157:106828-https://doi.org/10.1016/j.envint.2021.106828
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