ID Number		2308
Study Type		In Vivo
Model		Investigations on the thyroid, cerebral glucose metabolism, blood cells and the effect on body temperature with and without anesthesia in rats exposed to 915 MHz.
Details		AUTHORS' ABSTRACT: Kim et al. 2013 (IEEE #5309): As a part of an investigation on the potential risks of radiofrequency identification (RFID) on human health, we studied whether exposure to 915MHz RFID in rats significantly affected the secretory function of the thyroid system. A reverberation chamber was used as a whole-body exposure system. Male Sprague-Dawley rats were exposed for 8 h per day, 5 days per week, for a duration of 2, 4, 8, or 16 weeks. The estimated whole-body average specific absorption rate (SAR) varied from 3.2 to 4.6 W/kg depending on the age/mass of the animals for the field of the 915MHz RFID reader. Plasma levels of triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were evaluated via enzyme-linked immunosorbent assay. Morphological changes in the thyroid gland were then analyzed. No changes in T3, T4, or TSH were observed over time between the sham- and RFID-exposed groups. We suggest that subchronic exposure to 915 MHz RFID at a SAR of 4 W/kg does not cause significant effects on thyroid secretory function. AUTHORS' ABSTRACT: Kim et al. 2013 ((IEEE #5355): PURPOSE: We investigated the effect of whole-body exposure to 915-MHz radiofrequency identification (RFID) on rat cortical glucose metabolism by using (18)F-deoxyglucose positron emission tomography (FDG-PET). MATERIALS AND METHODS: Male Sprague-Dawley rats were divided into three groups: Cage-control, sham-exposed and RFID-exposed groups. Rats were exposed to the 915-MHz RFID for 8 h daily, 5 days per week, for 2 or 16 weeks. The whole-body average specific absorption rate (SAR) was 4 W/kg for the field of the 915 MHz RFID signal. FDG-PET images were obtained the day after RFID exposure, using micro-PET with a FDG tracer. With a Xeleris functional imaging workstation, absolute values in regions of interest (ROI) in the frontal, temporal and parietal cortexes and cerebellum were measured. Cortical ROI values were normalized to the cerebellar value and compared. RESULTS: The data showed that the relative cerebral glucose metabolic rate was unchanged in the frontal, temporal and parietal cortexes of the 915 MHz RFID-exposed rats, compared with rats in cage-control and sham-exposed groups. CONCLUSION: Our results suggest that 915 MHz RFID radiation exposure did not cause a significant long lasting effect on glucose metabolism in the rat brain. AUTHORS' ABSTRACT: Kim et al. 2017 (IEEE #6891): We investigated whether exposure to the 915 MHz radiofrequency identification (RFID) signal affected circulating blood cells in rats. SpragueDawley rats were exposed to RFID at a whole-body specific absorption rate of 2 W/kg for 8 h per day, 5 days per week, for 2 weeks. Complete blood counts were performed after RFID exposure, and the CD4+/CD8+ ratio was determined by flow cytometry. The number of red blood cells (RBCs) and the values of hemoglobin, hematocrit, and RBC indices were increased in the RFID-exposed group compared with those in the cage-control and sham-exposed groups (P < 0.05). However, the RBCs and platelet numbers were within normal physiologic response ranges. The number of white blood cells, including lymphocytes, was decreased in RFID-exposed rats. However, there was no statistically significant difference between the sham-exposed and RFID-exposed groups in terms of T-cell counts or CD4+/CD8+ ratio (P > 0.05). Although the number of circulating blood cells was significantly altered by RFID exposure at a whole-body specific absorption rate of 2 W/kg for 2 weeks, these changes do not necessarily indicate that RFID exposure is harmful, as they were within the normal physiological response range.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Korea Inst Radiol Med Sci, Korea - yslee@kcch.re.kr
Funding Agency		?????
Country		KOREA, REPUBLIC OF
References		Kim, HS et al. Bioelectromagnetics., (2013) 34:521-529 Kim , HS et al. Int J Radiat Biol., (2013) 89:750-755 Kim, HS et al. Bioelectromagnetics., (2018) 39:68-76 Kim, HS et al. Bioelectromagnetics., (2019) :- Paik, M-J et al. Amino acids., (2016) 48:213-217 Kim, HS et al. J Therm Biol. (71), 110:103350, (2022) 110:103350-
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